神经调节蛋白-1 在 A 型行为中起作用吗？芬兰年轻人心血管风险研究。
Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study.
机构信息
Department of Psychology, University of Helsinki, Finland.
出版信息
Behav Brain Funct. 2008 Sep 17;4:40. doi: 10.1186/1744-9081-4-40.
BACKGROUND
Neuregulin-1 proteins are related to physiological correlates of Type A in terms of cardiac reactivity. Furthermore, neuregulin-1 gene (NRG1) may play a role in cardiovascular disease such as atherosclerosis and coronary heart disease i.e. the suggested "outcomes" of Type A behavior. Therefore, NRG1 is hypothesized to be associated with Type A behavior.
METHODS
The study examined whether Type A behavior pattern is associated with the single nucleotide polymorphism (SNP) SNP8NRG221533 of the NRG1. The subjects were 631 men and women participating in the population-based Cardiovascular Risk in Young Finns study in 1992 and 2001. Type A was self-assessed with the Framingham Type A Scale and reassessed nine years later.
RESULTS
Type A was associated with NRG1 genotype. Carriers of genotype CC scored lower on Type A compared to the others.
CONCLUSION
Our study has pinpointed a SNP in NRG1 that predicts Type A behavior. As previous evidence suggests an association for NRG1 with beta-adrenergic stimulation, its role underlying Type A is discussed.
背景
神经调节蛋白-1 蛋白与心脏反应性方面的 A 型的生理相关因素有关。此外，神经调节蛋白-1 基因（NRG1）可能在心血管疾病中发挥作用，如动脉粥样硬化和冠心病，即 A 型行为的“结果”。因此，假设 NRG1 与 A 型行为有关。
方法
本研究探讨了 A 型行为模式是否与 NRG1 的单核苷酸多态性（SNP）SNP8NRG221533 有关。研究对象为 1992 年和 2001 年参加基于人群的芬兰年轻人心血管风险研究的 631 名男性和女性。A 型采用弗莱明汉 A 型量表进行自我评估，并在 9 年后重新评估。
结果
A 型与 NRG1 基因型有关。与其他基因型相比，CC 基因型携带者的 A 型得分较低。
结论
我们的研究已经确定了 NRG1 中的一个 SNP，它可以预测 A 型行为。由于先前的证据表明 NRG1 与β-肾上腺素刺激有关，因此讨论了其在 A 型行为中的作用。
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