Keltikangas-Järvinen Liisa, Hintsa Taina, Kivimäki Mika, Puttonen Sampsa, Juonala Markus, Viikari Jorma S A, Raitakari Olli T
Department of Psychology, University of Helsinki, P.O. Box 9, Finland.
Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1638-44. doi: 10.1161/ATVBAHA.107.145524. Epub 2007 May 10.
We examined the Type A behavior across developmental periods as a predictor of adult carotid artery intima-media thickness (IMT).
In this prospective cohort study of 408 men and 606 women, socioeconomic background and biological risk factors of participants were assessed at baseline at age 6 to 18 years of age, Type A behavior (Hunter-Wolf A-B Rating Scale) at the 6-, 9-, and 21-year follow-ups (subjects being 12 to 24, 15 to 27, and 27 to 39 years, respectively), and carotid IMT, adulthood socioeconomic situation, and biological risk factors at the 21-year follow-up when participants were at age 27 to 39 years of age. In men, the eagerness-energy component of Type A behavior, measured at any time point, was associated with thicker carotid IMT (P<0.008, P<0.04, P<0.03, and P<0.02 for the first, second, and third assessment, and for the average score, respectively), and this association was independent of early and adult risk factors. In women, the hard-driving component at baseline (P<0.04) but not later was independently related to thinner carotid IMT. The other components of Type A behavior (impatience-aggression and leadership) were not associated with IMT.
Eagerness-energy component of Type A behavior over different developmental transitions seems to be a robust predictor of IMT in men.
我们研究了不同发育阶段的A型行为作为成人颈动脉内膜中层厚度（IMT）预测指标的情况。
在这项针对408名男性和606名女性的前瞻性队列研究中，在基线时（6至18岁）评估了参与者的社会经济背景和生物学风险因素，在6年、9年和21年随访时（受试者分别为12至24岁、15至27岁和27至39岁）评估了A型行为（亨特 - 沃尔夫A - B评定量表），并在21年随访时（参与者27至39岁）评估了颈动脉IMT、成年期社会经济状况和生物学风险因素。在男性中，在任何时间点测量的A型行为的急切 - 活力成分与较厚的颈动脉IMT相关（第一次、第二次和第三次评估以及平均得分的P值分别<0.008、<0.04、<0.03和<0.02），并且这种关联独立于早期和成年期风险因素。在女性中，基线时的强硬驱力成分（P<0.04）与较薄的颈动脉IMT独立相关，但后期则不然。A型行为的其他成分（不耐烦 - 攻击性和领导力）与IMT无关。
在不同发育阶段，A型行为的急切 - 活力成分似乎是男性IMT的有力预测指标。
