Suvorov Alexander, Girard Sylvie, Lachapelle Sophie, Abdelouahab Nadia, Sebire Guillaume, Takser Larissa
Département d'Obstétrique Gynécologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Qué., Canada.
Neonatology. 2009;95(3):203-9. doi: 10.1159/000155651. Epub 2008 Sep 18.
Polybrominated diphenyl ethers (PBDE) are a group of environmental contaminants increasing in North America. Few data are available on neurobehavioral effects at low-dose exposure.
Our goal in the present study was to evaluate whether low-dose BDE-47, which is the most abundant PBDE in human samples, affects the neurobehavioral development of rats.
Dams were exposed to vehicle or low-dose BDE-47 (0.002, 0.02 and 0.2 mg/kg body weight) each 5 days from gestational day 15 to postnatal day (PND) 20 by intravenous injections. Spontaneous locomotor activity of pups was assessed using the open field test on PND 15, 20 and 25. Sensorimotor coordination was assessed using a RotaRod on PND 30.
Exposure to BDE-47 increased locomotor activity of pups. Developmental landmarks and sensorimotor coordination were not influenced by exposure to BDE-47. BDE-47 content in adipose tissue of exposed rats was similar to that known for human populations.
These results indicate neurodevelopmental disruption induced in rats by BDE-47 at levels found in the human population.
多溴二苯醚（PBDE）是北美地区日益增多的一类环境污染物。关于低剂量暴露下的神经行为效应的数据很少。
我们在本研究中的目标是评估低剂量的BDE - 47（人类样本中最常见的多溴二苯醚）是否会影响大鼠的神经行为发育。
从妊娠第15天至出生后第20天，每隔5天通过静脉注射，将母鼠暴露于赋形剂或低剂量的BDE - 47（0.002、0.02和0.2毫克/千克体重）。在出生后第15、20和25天，使用旷场试验评估幼崽的自发运动活动。在出生后第30天，使用转棒试验评估感觉运动协调性。
暴露于BDE - 47会增加幼崽的运动活动。发育里程碑和感觉运动协调性不受BDE - 47暴露的影响。暴露大鼠脂肪组织中的BDE - 47含量与已知的人类群体含量相似。
这些结果表明，BDE - 47在人类群体中发现的水平下会导致大鼠神经发育紊乱。
