Abdelouahab Nadia, Suvorov Alexander, Pasquier Jean-Charles, Langlois Marie-France, Praud Jean-Paul, Takser Larissa
Département d'Obstétrique et de Gynécologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Qué., Canada.
Neonatology. 2009;96(2):120-4. doi: 10.1159/000209316. Epub 2009 Mar 24.
The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 microg/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T(4) and T(3) in exposed lambs without any effect in pregnant sheep. Our finding indicates that prenatal low-dose PBDE exposure results in PBDE storage in fat of offspring and can affect thyroid metabolism in the developing fetus.
本研究的目的是评估人群中所报告水平的多溴二苯醚（PBDE）是否会影响怀孕母羊及其羔羊的甲状腺状态。怀孕母羊在妊娠第5至15周期间，通过每周静脉注射，接触媒介物或BDE-47（0.2、2和20微克/千克体重）。分析了绵羊、羔羊血液及脂肪组织中的甲状腺激素水平和BDE-47含量。我们观察到，暴露组羔羊的总T4和T3显著降低，而怀孕母羊未受任何影响。我们的研究结果表明，产前低剂量接触PBDE会导致PBDE在后代脂肪中蓄积，并可能影响发育中胎儿的甲状腺代谢。
