Kim Soyoung, Park Sung-Hee, Lee Hye-Nam, Park Taesun
Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Republic of Korea.
J Med Food. 2008 Sep;11(3):460-8. doi: 10.1089/jmf.2007.0097.
This study evaluated the effects of Prunus mume extract on exercise-induced fatigue recovery in a trained rat model. Male Sprague-Dawley rats were raised either on a control diet (EC) or on diets supplemented with 0.15% (0.15EP), 0.3% (0.3EP), or 0.9% (0.9EP) Prunus mume extract for 4 weeks (n = 18). Each dietary group was divided into two subgroups; at the end of the experimental period, one subgroup was sacrificed immediately after a 1-hour exercise, and the other subgroup was sacrificed after a 30-minute rest following the exercise (n = 9). Compared to the values for EC rats, serum ammonia concentration was significantly lower in 0.3EP and 0.9EP rats that were sacrificed immediately after the exercise-loading and in 0.15EP, 0.3EP and 0.9EP rats that were sacrificed after a 30-minute rest following the exercise. Compared to that in EC rats, serum lactate levels were significantly lower in rats fed 0.15% or higher levels of P. mume extract when they were sacrificed after a 30-minute rest following the exercise. Dietary supplementation with the P. mume extract significantly elevated hepatic and muscle glycogen concentrations of the rats sacrificed immediately after the exercise. P. mume extract significantly reduced lactate dehydrogenase activity and increased citrate synthase activity in the skeletal muscles of the rats sacrificed immediately after the exercise-loading. Taken together, these results indicate that the P. mume extract administered during endurance exercise training may enhance the oxidative capacity of exercising skeletal muscle and may induce the muscle to prefer fatty acids for its fuel use rather than amino acids or carbohydrates.
本研究评估了乌梅提取物对训练有素的大鼠模型运动性疲劳恢复的影响。将雄性斯普拉格-道利大鼠分为对照组（EC），以及分别补充0.15%（0.15EP）、0.3%（0.3EP）或0.9%（0.9EP）乌梅提取物的饮食组，喂养4周（n = 18）。每个饮食组再分为两个亚组；在实验期结束时，一个亚组在1小时运动后立即处死，另一个亚组在运动后休息30分钟后处死（n = 9）。与EC组大鼠的值相比，运动负荷后立即处死的0.3EP和0.9EP组大鼠以及运动后休息30分钟后处死的0.15EP、0.3EP和0.9EP组大鼠的血清氨浓度显著降低。与EC组大鼠相比，运动后休息30分钟后处死的喂食0.15%或更高水平乌梅提取物的大鼠的血清乳酸水平显著降低。饮食中补充乌梅提取物显著提高了运动后立即处死的大鼠的肝脏和肌肉糖原浓度。乌梅提取物显著降低了运动负荷后立即处死的大鼠骨骼肌中的乳酸脱氢酶活性，并增加了柠檬酸合酶活性。综上所述，这些结果表明，在耐力运动训练期间给予乌梅提取物可能会增强运动骨骼肌的氧化能力，并可能促使肌肉优先使用脂肪酸作为燃料，而不是氨基酸或碳水化合物。
