体外切除与致癌物4-硝基喹啉1-氧化物结合的DNA。
Excision in vitro of the DNA bound carcinogen, 4-nitroquinoline 1-oxide.
作者信息
Yoshida S, Tada M, Tada M
出版信息
Nucleic Acids Res. 1976 Nov;3(11):3227-33. doi: 10.1093/nar/3.11.3227.
Abstract
It has been shown that 4-hydroxyaminoquinoline 1-oxide, the proximate form of the carcinogen 4-nitroquinoline 1-oxide, binds covalently to the purine bases of DNA. Here we report that carcinogen-bound nucleotides can be excised from DNA by a 5' leads to 3' exonuclease associated with DNA polymerase I of E. coli in the forms of either mononucleotides or oligonucleotides. Beef spleen phosphodiesterase II (5' leads to 3') also split carcinogen-bound nucleotides, while a 3' leads to 5' exonuclease of DNA polymerase I and E. coli exonuclease III (3' leads to 5') could not excise the modified nucleotide.
摘要
业已表明，致癌物4-硝基喹啉1-氧化物的直接形式4-羟基氨基喹啉1-氧化物可与DNA的嘌呤碱基共价结合。在此我们报告，与大肠杆菌DNA聚合酶I相关的5'至3'核酸外切酶能够以单核苷酸或寡核苷酸的形式从DNA中切除与致癌物结合的核苷酸。牛脾磷酸二酯酶II（5'至3'）也能切割与致癌物结合的核苷酸，而DNA聚合酶I的3'至5'核酸外切酶和大肠杆菌核酸外切酶III（3'至5'）则无法切除修饰的核苷酸。
相似文献
1
Excision in vitro of the DNA bound carcinogen, 4-nitroquinoline 1-oxide.体外切除与致癌物4-硝基喹啉1-氧化物结合的DNA。
Nucleic Acids Res. 1976 Nov;3(11):3227-33. doi: 10.1093/nar/3.11.3227.
2
Inhibition of enzymic incision of thymine dimers by covalently bound guanine adducts of 4-nitroquinoline-1-oxide in DNA.
Cancer Res. 1986 May;46(5):2374-6.
3
In vitro DNA reaction with an ultimate carcinogen model of 4-nitroquinoline-1-oxide: the 4-acetoxyaminoquinoline-1-oxide. Enzymatic degradation of the modified DNA.与4-硝基喹啉-1-氧化物的终致癌物模型进行的体外DNA反应：4-乙酰氧基氨基喹啉-1-氧化物。修饰DNA的酶促降解。
Carcinogenesis. 1983;4(3):249-54. doi: 10.1093/carcin/4.3.249.
4
Main binding sites of the carcinogen, 4-nitroquinoline 1-oxide in nucleic acids.致癌物4-硝基喹啉1-氧化物在核酸中的主要结合位点。
Biochim Biophys Acta. 1976 Dec 13;454(3):558-66. doi: 10.1016/0005-2787(76)90281-1.
5
Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide.暴露于致癌物4-硝基喹啉1-氧化物的细胞DNA中8-羟基鸟嘌呤残基的形成。
Biochem Biophys Res Commun. 1986 Sep 14;139(2):626-32. doi: 10.1016/s0006-291x(86)80036-5.
6
Guanyl-C8-arylamination of DNA by the ultimate carcinogen of 4-nitroquinoline-1-oxide: a spectrophotometric titration.4-硝基喹啉-1-氧化物的最终致癌物对DNA的鸟嘌呤-C8-芳基胺化作用：分光光度滴定法
Anal Biochem. 1984 May 1;138(2):454-7. doi: 10.1016/0003-2697(84)90839-x.
7
Metabolism of 4-nitroquinoline 1-oxide and related compounds.4-硝基喹啉1-氧化物及相关化合物的代谢
Carcinog Compr Surv. 1981;6:25-45.
8
Enhanced bioreduction of 4-nitroquinoline 1-oxide by cultured ataxia telangiectasia cells.培养的共济失调毛细血管扩张症细胞对4-硝基喹啉1-氧化物的生物还原作用增强
Carcinogenesis. 1988 Sep;9(9):1711-5. doi: 10.1093/carcin/9.9.1711.
9
Reduction of 4-nitroquinoline 1-oxide to 4-hydroxyaminoquinoline 1-oxide in lysates of cytomegalovirus-infected cells.巨细胞病毒感染细胞裂解物中4-硝基喹啉1-氧化物还原为4-羟基氨基喹啉1-氧化物。
J Gen Virol. 1983 Nov;64 (Pt 11):2511-5. doi: 10.1099/0022-1317-64-11-2511.
10
Bioreduction of 4-nitroquinoline 1-oxide in dysplastic nevus syndrome fibroblasts.发育异常痣综合征成纤维细胞中4-硝基喹啉1-氧化物的生物还原作用
Mutat Res. 1989 Apr;225(4):165-9. doi: 10.1016/0165-7992(89)90114-0.
引用本文的文献
1
Impact of mobile phone-specific electromagnetic fields on DNA damage caused by occupationally relevant exposures: results of ex vivo experiments with peripheral blood mononuclear cells from different demographic groups.手机特定电磁场对职业相关暴露引起的 DNA 损伤的影响：不同人群外周血单个核细胞的离体实验结果。
Mutagenesis. 2023 Aug 24;38(4):227-237. doi: 10.1093/mutage/gead022.
2
The nucleotide-permeable Escherichia coli cell, a sensitive DNA repair indicator for carcinogens, mutagens, and antitumor agents binding covalently to DNA.核苷酸可通透的大肠杆菌细胞，一种用于检测致癌物、诱变剂和与DNA共价结合的抗肿瘤剂的灵敏DNA修复指示剂。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Sep 28;92(2):177-214. doi: 10.1007/BF00312409.
3
Carcinogen-induced DNA repair in nucleotide-permeable Escherichia coli cells. Analysis of DNA repair induced by carcinogenic K-region epoxides and 1,2,3,4-diepoxybutane.致癌物诱导的核苷酸通透型大肠杆菌细胞中的DNA修复。致癌K区环氧化物和1,2,3,4-二环氧丁烷诱导的DNA修复分析。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Sep 28;92(2):157-76. doi: 10.1007/BF00312408.
本文引用的文献
1
Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action.双功能烷化剂的细胞毒性作用及对该作用的抗性的分子机制。
Nature. 1965 May 1;206(983):480-3. doi: 10.1038/206480a0.
2
Photoreactivation of mutation and killing in Escherichia coli.大肠杆菌中突变和杀伤的光复活作用。
Adv Biol Med Phys. 1968;12:283-98. doi: 10.1016/b978-1-4831-9928-3.50015-1.
3
Exonuclease VII of Escherichia coli. Mechanism of action.大肠杆菌核酸外切酶VII。作用机制。
J Biol Chem. 1974 Jul 25;249(14):4553-61.
4
Excision of thymine dimers by proteolytic and amber fragments of E. coli DNA polymerase I.利用大肠杆菌DNA聚合酶I的蛋白水解片段和琥珀突变片段切除胸腺嘧啶二聚体
Biochem Biophys Res Commun. 1974 May 7;58(1):132-9. doi: 10.1016/0006-291x(74)90901-2.
5
The selective excision of arylalkylated products from the DNA of Escherichia coli treated with the carcinogen 7-bromomethylbenz(a)anthracene.
Biochim Biophys Acta. 1972 Nov 16;287(1):38-51. doi: 10.1016/0005-2787(72)90328-0.
6
7
Binding of 14 C-labeled 4-nitroquinoline 1-oxide to DNA in vivo.体内14C标记的4-硝基喹啉1-氧化物与DNA的结合
Chem Biol Interact. 1970 Apr;1(4):321-30. doi: 10.1016/0009-2797(70)90001-3.
8
Enzymatic activation of the carcinogen 4-hydroxyaminoquinoline-1-oxide and its interaction with cellular macromolecules.致癌物4-羟基氨基喹啉-1-氧化物的酶促活化及其与细胞大分子的相互作用。
Biochem Biophys Res Commun. 1972 Jan 31;46(2):1025-32. doi: 10.1016/s0006-291x(72)80244-4.
9
Interaction of a carcinogen, 4-nitroquinoline-1-oxide, with nucleic acids: chemical degradation of the adducts.致癌物4-硝基喹啉-1-氧化物与核酸的相互作用：加合物的化学降解
Chem Biol Interact. 1971 Jun;3(3):225-9. doi: 10.1016/0009-2797(71)90086-x.
10
Letter: Chemical structure of QAII, one of the covalently bound adducts of carcinogenic 4-nitroquinoline 1-oxide with nucleic acid bases of cellular nucleic acids.信函：致癌性4-硝基喹啉1-氧化物与细胞核酸碱基共价结合加合物之一QAII的化学结构。
Chem Pharm Bull (Tokyo). 1975 Nov;23(11):3041-3. doi: 10.1248/cpb.23.3041.
Zotero 插件