Tang Wei, Zeve Daniel, Suh Jae Myoung, Bosnakovski Darko, Kyba Michael, Hammer Robert E, Tallquist Michelle D, Graff Jonathan M
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Science. 2008 Oct 24;322(5901):583-6. doi: 10.1126/science.1156232. Epub 2008 Sep 18.
White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.
白色脂肪组织调节新陈代谢、繁殖和寿命。脂肪细胞在整个生命过程中形成，该细胞系在出生后阶段扩张最为显著。脂肪细胞与脉管系统协同发育，但体内白色脂肪祖细胞的身份和位置尚不清楚。我们使用基因标记小鼠来分离增殖和更新的脂肪生成祖细胞。我们发现，大多数脂肪细胞来源于这些增殖祖细胞池，这些祖细胞在出生前或出生后早期就已定向分化。这些祖细胞存在于脂肪脉管系统的壁细胞区室中，而非其他组织的脉管系统中。因此，脂肪脉管系统似乎起着祖细胞微环境的作用，可能为脂肪细胞发育提供信号。
