Domagalski Mikołaj, Olszańska Joanna, Pietraszek-Gremplewicz Katarzyna, Nowak Dorota
Department of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Obes Rev. 2025 Apr;26(4):e13873. doi: 10.1111/obr.13873. Epub 2025 Jan 6.
Colorectal cancer (CRC) is the third most common cancer worldwide and has one of the highest mortality rates. Considering its nonlinear etiology, many risk factors are associated with CRC formation and development, with obesity at the forefront. Obesity is regarded as one of the key environmental risk determinants for the pathogenesis of CRC. Excessive food intake and a sedentary lifestyle, together with genetic predispositions, lead to the overgrowth of adipose tissue along with a disruption in the number and function of its building cells. Adipose tissue-resident cells may constitute part of the CRC microenvironment. Alterations in their physiology and secretory profiles observed in obesity may further contribute to CRC progression, and despite similar localization, their contributions are not equivalent. They can interact with CRC cells, either directly or indirectly, influencing various processes that contribute to tumorigenesis. The main aim of this review is to provide insights into the diversity of adipose tissue resident cells, namely, adipocytes, adipose stromal cells, and immunological cells, regarding the role of particular cell types in co-forming the CRC microenvironment. The scope of this study was also devoted to the abnormalities in adipose tissue physiology observed in obesity states and their impact on CRC development.
结直肠癌（CRC）是全球第三大常见癌症，也是死亡率最高的癌症之一。鉴于其非线性病因，许多风险因素与CRC的形成和发展相关，其中肥胖最为突出。肥胖被视为CRC发病机制的关键环境风险决定因素之一。过量的食物摄入和久坐不动的生活方式，再加上遗传易感性，会导致脂肪组织过度生长，并使其构成细胞的数量和功能发生紊乱。驻留在脂肪组织中的细胞可能构成CRC微环境的一部分。在肥胖状态下观察到的它们的生理学和分泌谱改变可能会进一步促进CRC的进展，尽管它们的定位相似，但它们的作用并不相同。它们可以直接或间接地与CRC细胞相互作用，影响导致肿瘤发生的各种过程。本综述的主要目的是深入了解脂肪组织驻留细胞的多样性，即脂肪细胞、脂肪基质细胞和免疫细胞，以及特定细胞类型在共同形成CRC微环境中的作用。本研究的范围还涉及肥胖状态下观察到的脂肪组织生理学异常及其对CRC发展的影响。
