van der Zwan Leonard P, Teerlink Tom, Dekker Jacqueline M, Henry Ronald M A, Stehouwer Coen D A, Jakobs Cornelis, Heine Robert J, Scheffer Peter G
Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands.
J Lipid Res. 2009 Feb;50(2):342-9. doi: 10.1194/jlr.P800030-JLR200. Epub 2008 Sep 18.
Circulating oxidized LDL (oxLDL) levels are strongly correlated to LDL-cholesterol (LDL-c) and apolipoprotein-B100 (apoB100), making it difficult to disentangle their independent contributions to cardiovascular risk. We explored the determinants of oxLDL and the relation between oxLDL and flow-mediated dilation (FMD) of the brachial artery to investigate whether the oxLDL/LDL-c and oxLDL/apoB100 ratios are more informative than the separate variables. FMD of the brachial artery and plasma concentrations of oxLDL, LDL-cholesterol, and apoB100 were measured in 624 men and women (age range 50 to 87 years), participating in a population-based cohort study. OxLDL was strongly correlated with apoB100 (r = 0.82, P < 0.001) and LDL-c (r = 0.67, P < 0.001). Other major independent determinants of oxLDL were sex, HDL-cholesterol, and LDL particle size. LDL-c and apoB100 concentrations were not significantly associated with FMD. After adjustment for age, sex, glucose tolerance status, and Framingham risk score, the oxLDL/apoB100 ratio was negatively related to FMD (P = 0.017). This association was weaker for the oxLDL/ LDL-c ratio (P = 0.062) and absent for oxLDL level (P = 0.27). In contrast to oxLDL, the oxLDL/apoB100 ratio, and to a lesser extent the oxLDL/LDL-c ratio, are related to a functional measure of atherosclerosis. Therefore correction of oxLDL for LDL particle number may improve the clinical usefulness of oxLDL measurement.
循环氧化低密度脂蛋白（oxLDL）水平与低密度脂蛋白胆固醇（LDL-c）和载脂蛋白B100（apoB100）密切相关，因此难以区分它们对心血管风险的独立影响。我们探究了oxLDL的决定因素以及oxLDL与肱动脉血流介导的血管舒张（FMD）之间的关系，以研究oxLDL/LDL-c和oxLDL/apoB100比值是否比单独的变量更具信息量。在一项基于人群的队列研究中，对624名男性和女性（年龄范围50至87岁）测量了肱动脉FMD以及oxLDL、LDL-胆固醇和apoB100的血浆浓度。oxLDL与apoB100（r = 0.82，P < 0.001）和LDL-c（r = 0.67，P < 0.001）密切相关。oxLDL的其他主要独立决定因素为性别、高密度脂蛋白胆固醇和LDL颗粒大小。LDL-c和apoB100浓度与FMD无显著关联。在调整年龄、性别、糖耐量状态和弗雷明汉风险评分后，oxLDL/apoB100比值与FMD呈负相关（P = 0.017）。oxLDL/LDL-c比值的这种关联较弱（P = 0.062），而oxLDL水平则无此关联（P = 0.27）。与oxLDL不同，oxLDL/apoB100比值以及在较小程度上oxLDL/LDL-c比值与动脉粥样硬化的功能指标相关。因此，用LDL颗粒数量校正oxLDL可能会提高oxLDL测量的临床实用性。
