National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Dept. of Food and Nutrition, College of Human Ecology, Yonsei Univ., Seoul, Republic of Korea.
Nutr Metab Cardiovasc Dis. 2011 Feb;21(2):136-43. doi: 10.1016/j.numecd.2009.08.003. Epub 2009 Oct 23.
To investigate the association of plasma total homocysteine (tHcy) with arterial stiffness, measured as brachial-ankle pulse wave velocity (baPWV), LDL atherogenicity, and inflammation profile in healthy men.
In this cross-sectional study, 612 healthy men aged 31-79 years were classified into quartiles according to plasma tHcy concentration. In the total study population, tHcy concentration showed positive correlation with age (r=0.083, P=0.040), interleukin (IL)-1β (r=0.249, P<0.001), TNF-α (r=0.150, P<0.001), IL-6 (r=0.154, P<0.001), oxidized LDL (oxLDL) (r=0.161, P=<0.001), and baPWV (r=0.087, P=0.032); and negative correlation with folate (r=-0.353, P<0.001) and vitamin B(12) (r=-0.269, P<0.001). In subgroup analysis based on plasma tHcy level, tHcy was associated with baPWV in men with high levels of tHcy (≥ 13.1μmol/L, n=153; r=0.258, P=0.001), but not in those with low-tHcy (<13.1 μmol/L, n=459; r=-0.033, P=0.478). The association between tHcy and baPWV in the high-tHcy group remained significant after adjustment for age, BMI, smoking, drinking, folate, and vitamin B₁₂. In the high-tHcy group, tHcy level was also positively correlated with IL-1β, TNF-α, oxLDL, and blood pressure; and negatively correlated with LDL particle size. In addition, baPWV showed negative correlation with LDL particle size and positive correlation with oxLDL in the high-tHcy group.
This study shows an association between high levels of plasma tHcy and more advanced arterial stiffness, smaller LDL particle size, and higher levels of oxLDL and cytokines in men with hyperhomocysteinemia. Enhanced arterial stiffness in hyperhomocysteinemia might be attributed, in part, to Hcy-related LDL atherogenicity.
研究血浆总同型半胱氨酸（tHcy）与肱踝脉搏波速度（baPWV）、LDL 致动脉粥样硬化性、炎症谱在健康男性中的相关性，以评估其与动脉僵硬度的关系。
在这项横断面研究中，根据血浆 tHcy 浓度将 612 名年龄在 31-79 岁的健康男性分为四组。在整个研究人群中，tHcy 浓度与年龄呈正相关（r=0.083，P=0.040），与白细胞介素（IL）-1β（r=0.249，P<0.001）、肿瘤坏死因子-α（r=0.150，P<0.001）、IL-6（r=0.154，P<0.001）、氧化型低密度脂蛋白（oxLDL）（r=0.161，P<0.001）和 baPWV（r=0.087，P=0.032）呈正相关；与叶酸（r=-0.353，P<0.001）和维生素 B12（r=-0.269，P<0.001）呈负相关。基于血浆 tHcy 水平的亚组分析显示，tHcy 与高 tHcy 水平（≥13.1μmol/L，n=153；r=0.258，P=0.001）男性的 baPWV 相关，但与低 tHcy 水平（<13.1μmol/L，n=459；r=-0.033，P=0.478）男性的 baPWV 不相关。在调整年龄、BMI、吸烟、饮酒、叶酸和维生素 B₁₂ 后，高 tHcy 组中 tHcy 与 baPWV 之间的关联仍然显著。在高 tHcy 组中，tHcy 水平与 IL-1β、TNF-α、oxLDL 和血压呈正相关，与 LDL 颗粒大小呈负相关。此外，在高 tHcy 组中，baPWV 与 LDL 颗粒大小呈负相关，与 oxLDL 呈正相关。
本研究表明，高血浆 tHcy 水平与男性动脉僵硬度增加、LDL 颗粒减小、oxLDL 和细胞因子水平升高有关。高同型半胱氨酸血症增强的动脉僵硬度部分归因于 Hcy 相关的 LDL 致动脉粥样硬化性。
