金属配合物与血清白蛋白可逆结合中的对映选择性调控：圆偏振发光信号的动态螺旋度反转
Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence.
作者信息
Montgomery Craig P, New Elizabeth J, Parker David, Peacock Robert D
机构信息
Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE.
出版信息
Chem Commun (Camb). 2008 Sep 28(36):4261-3. doi: 10.1039/b810978h. Epub 2008 Sep 10.
DOI:10.1039/b810978h
PMID:18802537
Abstract
The helicity of the (SSS)-Delta enantiomer of a terbium and europium(III) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Lambda complexes, thereby defining a unique chiroptical probe of albumin binding.
摘要
铽和铕（III）配合物的（SSS）-Δ对映体的螺旋度在与血清白蛋白的“药物位点II”可逆结合时发生反转，这通过其圆偏振发射的转变得以体现；而（RRR）-Λ配合物则没有这种行为，从而定义了一种独特的白蛋白结合手性光学探针。
Zotero 插件