Department of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St, Bucharest 020956, Romania.
Molecules. 2020 Mar 16;25(6):1347. doi: 10.3390/molecules25061347.
Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytical applications. Interestingly, lanthanide ions possess extremely attractive properties that result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. Subsequently, a more detailed discussion about metal complexes of quinolones with lanthanide ions in terms of chemical and biological properties is made. These complexes present a series of characteristics, such as narrow and highly structured emission bands; large gaps between absorption and emission wavelengths (Stokes shifts); and long excited-state lifetimes, which render them suitable for highly sensitive and selective analytical methods of quantitation. Moreover, quinolones have been widely prescribed in both human and animal treatments, which has led to an increase in their impact on the environment, and therefore to a growing interest in the development of new methods for their quantitative determination. Therefore, analytical applications for the quantitative determination of quinolones, lanthanide and miscellaneous ions and nucleic acids, along with other applications, are reviewed here.
喹诺酮类药物是一类具有广谱活性和良好生物利用度的合成杀菌药物。这些分子的一个重要特征是它们能够与相关的生物和分析应用中的金属离子形成配合物。有趣的是，镧系离子具有极其吸引人的性质，这是由于内部 4f 电子的行为所致，这种行为在电离后或配位后不会丢失。随后，本文就喹诺酮类药物与镧系离子的金属配合物在化学和生物学性质方面进行了更详细的讨论。这些配合物具有一系列特点，如窄而高度结构化的发射带；吸收和发射波长之间的大间隙（Stokes 位移）；以及长激发态寿命，这使得它们适合于高度灵敏和选择性的定量分析方法。此外，喹诺酮类药物在人类和动物治疗中被广泛应用，这导致它们对环境的影响增加，因此人们越来越关注开发新的定量测定方法。因此，本文综述了定量测定喹诺酮类药物、镧系和杂离子以及核酸的分析应用以及其他应用。
