Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, 518000, P. R. China.
Angew Chem Int Ed Engl. 2021 Jan 11;60(2):1004-1010. doi: 10.1002/anie.202012133. Epub 2020 Nov 3.
Chirality is ubiquitous within biological systems where many of the roles and functions are still undetermined. Given this, there is a clear need to design and develop sensitive chiral optical probes that can function within a biological setting. Here we report the design and synthesis of magnetically responsive Circularly Polarized Luminescence (CPL) complexes displaying exceptional photophysical properties (quantum yield up to 31 % and |g | up to 0.240) by introducing chiral substituents onto the macrocyclic scaffolds. Magnetic CPL responses are observed in these chiral Eu complexes, promoting an exciting development to the field of magneto-optics. The |g | of the D → F transition increases by 20 % from 0.222 (0 T) to 0.266 (1.4 T) displaying a linear relationship between the Δg and the magnetic field strength. These Eu complexes with magnetic CPL responses, provides potential development to be used in CPL imaging applications due to improved sensitivity and resolution.
手性在生物系统中无处不在，其中许多作用和功能仍未确定。鉴于此，显然需要设计和开发能够在生物环境中发挥作用的灵敏手性光学探针。在这里，我们报告了通过在大环支架上引入手性取代基来设计和合成具有出色光物理性质（量子产率高达 31%，|g|高达 0.240）的磁响应圆偏振发光（CPL）配合物。在这些手性 Eu 配合物中观察到磁 CPL 响应，为磁光学领域的发展带来了令人兴奋的进展。D→F 跃迁的|g|从 0.222（0 T）增加到 0.266（1.4 T），增加了 20%，表明 g 值与磁场强度之间存在线性关系。这些具有磁 CPL 响应的 Eu 配合物，由于灵敏度和分辨率的提高，为 CPL 成像应用提供了潜在的发展。
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