氟甲基酮的对映选择性有机催化亨利反应。
Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones.
作者信息
Bandini Marco, Sinisi Riccardo, Umani-Ronchi Achille
机构信息
Dipartimento di Chimica G. Ciamician, Università di Bologna, Via Selmi 2, 40126, Bologna, Italy.
出版信息
Chem Commun (Camb). 2008 Sep 28(36):4360-2. doi: 10.1039/b807640e. Epub 2008 Jul 24.
DOI:10.1039/b807640e
PMID:18802570
Abstract
Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76-99%) under mild reaction conditions and low loading of catalyst (1-5 mol%).
摘要
本文展示了新型带有吸电子取代基的C9-苯甲酰基铜试剂在与氟甲基酮进行硝基羟醛缩合反应时，具有显著的广泛适用性。在温和的反应条件下，使用低负载量的催化剂（1-5 mol%），三氟甲基酮和二氟甲基酮都能提供优异的立体诱导水平（对映体过量率为76-99%）。
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