亚烷基氧化吲哚对三氟甲基-α,β-不饱和酮的不对称乙烯型羟醛加成反应。

Asymmetric vinylogous aldol addition of alkylidene oxindoles on trifluoromethyl-α,β-unsaturated ketones.

作者信息

Crotti Simone, Belletti Giada, Di Iorio Nicola, Marotta Emanuela, Mazzanti Andrea, Righi Paolo, Bencivenni Giorgio

机构信息

Department of Industrial Chemistry "Toso Montanari", Alma Mater Studiorum-University of Bologna Viale del Risorgimento 4 40136-Bologna Italy

出版信息

RSC Adv. 2018 Sep 28;8(58):33451-33458. doi: 10.1039/c8ra06615a. eCollection 2018 Sep 24.

A novel vinylogous aldol addition of alkylidene oxindole with 1-trifluoromethyl-3-alkylidene-propan-2-ones is presented. The reaction, catalyzed by a bifunctional tertiary amine, provides an efficient application of the vinylogous reactivity of oxindoles for the preparation of enantioenriched trifluoromethylated allylic alcohols.