RhoGTPases在轴突包裹和髓鞘形成中的作用。
The function of RhoGTPases in axon ensheathment and myelination.
作者信息
Feltri M Laura, Suter Ueli, Relvas João B
机构信息
DIBIT, San Raffaele Scientific Institute, Milano, Italy.
Institute of Cell Biology, Department of Biology, Eidgenössische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland.
出版信息
Glia. 2008 Nov 1;56(14):1508-1517. doi: 10.1002/glia.20752.
RhoGTPases are molecular switches that integrate extracellular signals to perform diverse cellular responses. This ability relies on the network of proteins regulating RhoGTPases activity and localization, and on the interaction of RhoGTPases with many different cellular effectors. Myelination is an ideal place for RhoGTPases regulation, as it is the result of fine orchestration of many stimuli from at least two cell types. Recent work has revealed that RhoGTPases are required for Schwann cells to sort, ensheath, and myelinate axons. Here, we will review these recent advances showing the critical roles for RhoGTPases in various aspects of Schwann development and myelination, including the recent discovery of their involvement in Charcot-Marie-Tooth disease. Comparison with potential roles of RhoGTPases in central nervous system myelination will be drawn.
RhoGTPases是分子开关，可整合细胞外信号以执行多种细胞反应。这种能力依赖于调节RhoGTPases活性和定位的蛋白质网络，以及RhoGTPases与许多不同细胞效应器的相互作用。髓鞘形成是RhoGTPases调节的理想场所，因为它是至少两种细胞类型的许多刺激精细协调的结果。最近的研究表明，RhoGTPases是施万细胞对轴突进行分类、包裹和髓鞘形成所必需的。在这里，我们将回顾这些最新进展，展示RhoGTPases在施万细胞发育和髓鞘形成的各个方面的关键作用，包括最近发现它们与夏科-马里-图斯病的关联。还将与RhoGTPases在中枢神经系统髓鞘形成中的潜在作用进行比较。
Zotero 插件