Park Y, Pariza M W, Park Y
Dept of Food Science, Univ of Massachusetts Amherst, Amherst, MA 01002, USA.
J Food Sci. 2008 Sep;73(7):C556-60. doi: 10.1111/j.1750-3841.2008.00861.x. Epub 2008 Jul 24.
Conjugated linoleic acid (CLA) has shown a variety of biologically beneficial effects, such as anticancer, antiatherosclerosis, antidiabetic, immunomodulating, and antiobesity effects. Its effects on reduction of body fat occur with enhancement of lean body mass and body ash; the effects of CLA on bone mass are inconsistent in mice and human studies. We hypothesized that the inconsistency of CLA's effect on ash may be linked to interaction between CLA and dietary calcium levels. We reanalyzed our previous studies, which used mice fed 0.5% CLA-containing diet with regular calcium content (0.5%) or enhanced calcium level (0.66%). Extra calcium in the diet improved CLA's effects on bone mass, particularly in male mice (P= 0.0194); without extra dietary calcium there was no effect of CLA on bone mass. This finding may help improve the efficacy of CLA to be used as a dietary supplement to be used as part of an osteoporosis prevention strategy. Further studies are needed to confirm this observation.
共轭亚油酸（CLA）已显示出多种生物学有益作用，如抗癌、抗动脉粥样硬化、抗糖尿病、免疫调节和抗肥胖作用。其减少体脂的作用伴随着瘦体重和体灰分的增加；CLA对骨量的影响在小鼠和人体研究中并不一致。我们推测，CLA对灰分影响的不一致可能与CLA和膳食钙水平之间的相互作用有关。我们重新分析了我们之前的研究，这些研究使用喂食含0.5%CLA饮食的小鼠，其钙含量正常（0.5%）或钙水平提高（0.66%）。饮食中额外的钙改善了CLA对骨量的影响，尤其是在雄性小鼠中（P = 0.0194）；没有额外的膳食钙时，CLA对骨量没有影响。这一发现可能有助于提高CLA作为膳食补充剂用于骨质疏松症预防策略一部分的功效。需要进一步的研究来证实这一观察结果。
