Rahman Md Mizanur, Bhattacharya Arunabh, Banu Jameela, Fernandes Gabriel
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.
J Nutr Biochem. 2007 Jul;18(7):467-74. doi: 10.1016/j.jnutbio.2006.08.002. Epub 2006 Sep 25.
Osteoporosis is one of the major causes of morbidity in the elderly. Inflammation exerts a significant influence on bone turnover, inducing the chronic form of osteoporosis. Dietary nutrition has the capacity to modulate inflammatory response. Therefore, nutritional strategies and lifestyle changes may prevent age-related osteoporosis, thereby improving the quality of life of the elderly population. Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism. Hence, this study was undertaken to examine the effect of CLA on bone mineral density (BMD) in middle-aged C57BL/6 female mice. After 10 weeks on diet, CLA-fed mice (14 months) maintained a higher BMD in different bone regions than corn oil (CO)-fed mice. The increased BMD was accompanied by a decreased activity of proinflammatory cytokines (such as tumor necrosis factor alpha, interleukin-6 and the receptor activator of NF-kappaB ligand) and decreased osteoclast function. Furthermore, a significant decrease in fat mass and an increase in muscle mass were also observed in CLA-fed mice compared to CO-fed mice. In conclusion, these findings suggest that CLA may prevent the loss of bone and muscle mass by modulating markers of inflammation and osteoclastogenic factors.
骨质疏松症是老年人发病的主要原因之一。炎症对骨转换有显著影响，可诱发慢性骨质疏松症。膳食营养能够调节炎症反应。因此，营养策略和生活方式的改变可能预防与年龄相关的骨质疏松症，从而提高老年人群的生活质量。共轭亚油酸（CLA）已被证明对钙和骨代谢有积极影响。因此，本研究旨在检测CLA对中年C57BL/6雌性小鼠骨密度（BMD）的影响。在饮食10周后，喂食CLA的小鼠（14个月）在不同骨区域的骨密度高于喂食玉米油（CO）的小鼠。骨密度增加伴随着促炎细胞因子（如肿瘤坏死因子α、白细胞介素-6和核因子κB受体激活剂配体）活性降低以及破骨细胞功能下降。此外，与喂食CO的小鼠相比，喂食CLA的小鼠脂肪量显著减少，肌肉量增加。总之，这些发现表明CLA可能通过调节炎症标志物和破骨细胞生成因子来预防骨量和肌肉量的流失。
