共轭亚油酸对骨生理学的影响：涉及抑制脂肪生成的拟议机制。
Impact of conjugated linoleic acid on bone physiology: proposed mechanism involving inhibition of adipogenesis.
机构信息
Division of Endocrinology, Diabetes, & Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210-1296, USA.
出版信息
Nutr Rev. 2011 Mar;69(3):123-31. doi: 10.1111/j.1753-4887.2011.00376.x. Epub 2011 Feb 14.
Abstract
Conjugated linoleic acid (CLA) supplementation decreases adipose mass and increases bone mass in mice. Recent clinical studies demonstrate a beneficial effect of CLA on reducing weight and adipose mass in humans. This article reviews possible biological mechanisms of action of CLA on bone metabolism, focusing on modulation of nuclear receptor peroxisome proliferator-activated receptor gamma activity to steer mesenchymal stem cell differentiation toward an adipose and away from an osteoblast lineage. Clinical studies of the effects of CLA on bone mass and clinical implications of the effects of CLA on bone health in humans are summarized and discussed.
摘要
共轭亚油酸（CLA）补充剂可减少脂肪量并增加小鼠的骨量。最近的临床研究表明 CLA 对减少人体体重和脂肪量具有有益作用。本文综述了 CLA 对骨代谢可能的作用机制，重点是调节核受体过氧化物酶体增殖物激活受体 γ 的活性，促使间充质干细胞向脂肪细胞分化，而不是向成骨细胞分化。总结并讨论了 CLA 对骨量的影响的临床研究以及 CLA 对人类骨骼健康的影响的临床意义。
相似文献
1
Impact of conjugated linoleic acid on bone physiology: proposed mechanism involving inhibition of adipogenesis.共轭亚油酸对骨生理学的影响：涉及抑制脂肪生成的拟议机制。
Nutr Rev. 2011 Mar;69(3):123-31. doi: 10.1111/j.1753-4887.2011.00376.x. Epub 2011 Feb 14.
2
Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance.膳食共轭亚油酸可增加肥胖大鼠脂肪组织中PPARγ基因的表达，并改善胰岛素抵抗。
Growth Horm IGF Res. 2008 Oct;18(5):361-368. doi: 10.1016/j.ghir.2008.01.001. Epub 2008 Mar 4.
3
trans-10,cis-12 conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ-dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells.反式-10，顺式-12 共轭亚油酸通过过氧化物酶体增殖物激活受体-γ 依赖性机制抑制脂肪生成，并通过直接增强骨髓间充质干细胞向成骨细胞的分化来促进骨形成。
J Nutr Biochem. 2013 Apr;24(4):672-9. doi: 10.1016/j.jnutbio.2012.03.017. Epub 2012 Jul 23.
4
Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment.反式10，顺式12共轭亚油酸在脂肪细胞分化过程中对脂质积累的抑制作用取决于处理的时间和时长。
Biochim Biophys Acta. 2005 Feb 21;1687(1-3):11-22. doi: 10.1016/j.bbalip.2004.08.018.
5
Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect.共轭亚油酸负载生育酚纳米载体易于被脂肪细胞摄取并递送至肝脏/脂肪组织，从而产生协同抗脂肪生成作用。
J Nanobiotechnology. 2024 Feb 6;22(1):50. doi: 10.1186/s12951-024-02316-8.
6
Trans10, cis12 conjugated linoleic acid inhibits 3T3-L1 adipocyte adipogenesis by elevating β-catenin levels.反式10，顺式12共轭亚油酸通过提高β-连环蛋白水平抑制3T3-L1脂肪细胞的脂肪生成。
Biochim Biophys Acta. 2016 Apr;1861(4):363-70. doi: 10.1016/j.bbalip.2016.01.004. Epub 2016 Jan 9.
7
Adipocyte response to conjugated linoleic acid.脂肪细胞对共轭亚油酸的反应。
Obes Res Clin Pract. 2013 Jul-Aug;7(4):e235-42. doi: 10.1016/j.orcp.2013.04.002.
8
Modulation of peroxisome proliferator-activated receptor gamma (PPAR γ) by conjugated fatty acid in obesity and inflammatory bowel disease.共轭脂肪酸对肥胖和炎症性肠病中过氧化物酶体增殖物激活受体γ（PPARγ）的调节作用
J Agric Food Chem. 2015 Feb 25;63(7):1883-95. doi: 10.1021/jf505050c. Epub 2015 Feb 12.
9
Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice.罗格列酮与共轭亚油酸联合对高脂喂养小鼠肥胖、胰岛素敏感性及肝脂肪变性的影响
Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1671-82. doi: 10.1152/ajpgi.00523.2006. Epub 2007 Feb 22.
10
Conjugated linoleic acid (t-10, c-12) reduces fatty acid synthesis de novo, but not expression of genes for lipid metabolism in bovine adipose tissue ex vivo.共轭亚油酸（反式-10，顺式-12）可减少脂肪酸的从头合成，但对体外培养的牛脂肪组织中脂质代谢相关基因的表达没有影响。
Lipids. 2014 Jan;49(1):15-24. doi: 10.1007/s11745-013-3869-0. Epub 2013 Nov 30.
引用本文的文献
1
Short-term high-fat diet impacts bone material properties and metabolism for adult and aged C57BL/6JN mice.短期高脂饮食对成年和老年C57BL/6JN小鼠的骨材料特性和代谢产生影响。
Commun Biol. 2025 Jun 3;8(1):850. doi: 10.1038/s42003-025-08263-w.
2
Conjugated linoleic acid and glucosamine supplements may prevent bone loss in aging by regulating the RANKL/RANK/OPG pathway.共轭亚油酸和氨基葡萄糖补充剂可能通过调节RANKL/RANK/OPG通路来预防衰老过程中的骨质流失。
Mol Biol Rep. 2023 Dec;50(12):10579-10588. doi: 10.1007/s11033-023-08839-x. Epub 2023 Nov 6.
3
Probiotic Properties of Lactic Acid Bacteria with High Conjugated Linoleic Acid Converting Activity Isolated from , High-Salt Fermented Seafood.从高盐发酵海鲜中分离出的具有高共轭亚油酸转化活性的乳酸菌的益生菌特性
Microorganisms. 2021 Oct 28;9(11):2247. doi: 10.3390/microorganisms9112247.
4
A critical review of the role of milk and other dairy products in the development of obesity in children and adolescents.牛奶及其他乳制品在儿童和青少年肥胖发展中的作用的批判性回顾。
Nutr Res Rev. 2019 Jun;32(1):106-127. doi: 10.1017/S0954422418000227. Epub 2018 Nov 27.
5
The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD.共轭亚油酸对慢性阻塞性肺疾病患者氧化应激及基质金属蛋白酶2和9的影响
Int J Chron Obstruct Pulmon Dis. 2018 May 3;13:1449-1454. doi: 10.2147/COPD.S155985. eCollection 2018.
6
The effect of conjugated linoleic acid supplementation on the nutritional status of COPD patients.共轭亚油酸补充剂对慢性阻塞性肺疾病患者营养状况的影响。
Int J Chron Obstruct Pulmon Dis. 2016 Oct 31;11:2711-2720. doi: 10.2147/COPD.S111629. eCollection 2016.
7
Canola Oil in Lactating Dairy Cow Diets Reduces Milk Saturated Fatty Acids and Improves Its Omega-3 and Oleic Fatty Acid Content.泌乳奶牛日粮中的菜籽油可降低牛奶中的饱和脂肪酸含量，并提高其Omega-3和油酸含量。
PLoS One. 2016 Mar 25;11(3):e0151876. doi: 10.1371/journal.pone.0151876. eCollection 2016.
8
Individual CLA Isomers, c9t11 and t10c12, Prevent Excess Liver Glycogen Storage and Inhibit Lipogenic Genes Expression Induced by High-Fructose Diet in Rats.个别共轭亚油酸异构体，c9t11和t10c12，可防止大鼠肝脏糖原过度储存，并抑制高果糖饮食诱导的生脂基因表达。
Biomed Res Int. 2015;2015:535982. doi: 10.1155/2015/535982. Epub 2015 May 18.
9
Nitrogen-containing bisphosphonates modulate the antigenic profile and inhibit the maturation and biomineralization potential of osteoblast-like cells.含氮双膦酸盐可调节抗原谱并抑制成骨样细胞的成熟和生物矿化潜能。
Clin Oral Investig. 2015 May;19(4):895-902. doi: 10.1007/s00784-014-1309-z. Epub 2014 Aug 28.
10
Nuclear receptors and epigenetic regulation: opportunities for nutritional targeting and disease prevention.核受体与表观遗传调控：营养靶向与疾病预防的机遇
Adv Nutr. 2014 Jul 14;5(4):373-85. doi: 10.3945/an.114.005868. Print 2014 Jul.
本文引用的文献
1
Interaction between dietary conjugated linoleic acid and calcium supplementation affecting bone and fat mass.膳食共轭亚油酸与钙补充剂的相互作用影响骨量和体脂量。
J Bone Miner Metab. 2011 May;29(3):268-78. doi: 10.1007/s00774-010-0212-1. Epub 2010 Aug 10.
2
Effect of conjugated linoleic acid on body fat accretion in overweight or obese children.共轭亚油酸对超重或肥胖儿童体脂肪积累的影响。
Am J Clin Nutr. 2010 May;91(5):1157-64. doi: 10.3945/ajcn.2009.28404. Epub 2010 Mar 3.
3
Thiazolidinediones and fractures in men and women.噻唑烷二酮类药物与男性和女性的骨折
Arch Intern Med. 2009 Aug 10;169(15):1395-402. doi: 10.1001/archinternmed.2009.214.
4
Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus.饮食中共轭亚油酸与红花油对肥胖绝经后2型糖尿病女性身体成分的影响比较。
Am J Clin Nutr. 2009 Sep;90(3):468-76. doi: 10.3945/ajcn.2008.27371. Epub 2009 Jun 17.
5
Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training.在力量训练期间，共轭亚油酸与一水肌酸和乳清蛋白补充剂联合使用。
Int J Sport Nutr Exerc Metab. 2009 Feb;19(1):79-96. doi: 10.1123/ijsnem.19.1.79.
6
PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells.PPARγ2核受体调控骨髓间充质干细胞向成骨细胞分化的多条调控途径。
J Cell Biochem. 2009 Feb 1;106(2):232-46. doi: 10.1002/jcb.21994.
7
Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.噻唑烷二酮类药物的长期使用与2型糖尿病骨折：一项荟萃分析。
CMAJ. 2009 Jan 6;180(1):32-9. doi: 10.1503/cmaj.080486. Epub 2008 Dec 10.
8
Regulation of osteoblast and adipocyte differentiation from human mesenchymal stem cells by conjugated linoleic acid.共轭亚油酸对人骨髓间充质干细胞向成骨细胞和脂肪细胞分化的调控作用。
J Nutr Biochem. 2009 Dec;20(12):956-64. doi: 10.1016/j.jnutbio.2008.08.008. Epub 2008 Nov 18.
9
Cosupplementation of dietary calcium and conjugated linoleic acid (CLA) improves bone mass in mice.膳食钙与共轭亚油酸（CLA）联合补充可提高小鼠的骨量。
J Food Sci. 2008 Sep;73(7):C556-60. doi: 10.1111/j.1750-3841.2008.00861.x. Epub 2008 Jul 24.
10
Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female mice.共轭亚油酸和运动对中年雌性小鼠骨骼的有益作用。
J Bone Miner Metab. 2008;26(5):436-45. doi: 10.1007/s00774-008-0863-3. Epub 2008 Aug 30.
Zotero 插件