von Döhren Hans
Technical University Berlin, Institute of Chemistry OE2, Franklinstr. 29, 10587 Berlin, Germany.
Fungal Genet Biol. 2009 Mar;46 Suppl 1:S45-52. doi: 10.1016/j.fgb.2008.08.008. Epub 2008 Sep 3.
The genome of Aspergillus nidulans carries 27 genes encoding nonribosomal peptide synthetase (NRPS) structures, although only five of these forming peptides and amino acid containing metabolites have been identified so far. This manuscript describes domain structures, substrate binding pockets and related genes and gene clusters and summarizes our current state of product prediction of fungal NRPS systems.
构巢曲霉的基因组含有27个编码非核糖体肽合成酶（NRPS）结构的基因，尽管到目前为止仅鉴定出其中5个形成含肽和氨基酸代谢物的基因。本文描述了结构域结构、底物结合口袋以及相关基因和基因簇，并总结了我们目前对真菌NRPS系统产物预测的现状。
