同种异体移植物与骨形态发生蛋白：综述

Allograft and bone morphogenetic proteins: an overview.

作者信息

Blokhuis T J, Lindner T

机构信息

Department of Surgery/Traumatology, University Nijmegen Medical Center, Nijmegen, The Netherlands.

出版信息

Injury. 2008 Sep;39 Suppl 2:S33-6. doi: 10.1016/S0020-1383(08)70013-5.

DOI:10.1016/S0020-1383(08)70013-5

PMID:18804571

Abstract

Allograft is frequently used in orthopaedic and trauma surgery. On top of safety issues its biological activity is limited also due to processing. Consequently, the combination of allograft with osteoinductive substances may increase its effectiveness and decrease failure rates. In particular Bone Morphogenetic Proteins (BMPs) seem to be a promising partner for clinical applications. This overview focuses on the combined application of allograft/BMPs. Current points of view from available literature are summarized.

摘要

同种异体移植物在骨科和创伤手术中经常使用。除了安全问题外，由于处理过程，其生物活性也受到限制。因此，同种异体移植物与骨诱导物质的组合可能会提高其有效性并降低失败率。特别是骨形态发生蛋白（BMPs）似乎是临床应用中一个有前景的搭档。本综述重点关注同种异体移植物/BMPs的联合应用。总结了现有文献中的当前观点。