骨形态发生蛋白科学与研究

Bone morphogenic protein science and studies.

作者信息

Lane Joseph M

机构信息

Hospital for Special Surgery, New York, NY 10021, USA.

出版信息

J Orthop Trauma. 2005 Nov-Dec;19(10 Suppl):S17-22. doi: 10.1097/00005131-200511101-00006.

DOI:10.1097/00005131-200511101-00006

PMID:16479218

Abstract

The use of growth factors, such as bone morphogenic proteins (BMPs), is showing great promise in orthopaedic surgery. The BMPs, which are osteoinductive, have been used successfully in spine fusion and fracture healing. This article describes the development and production of the recombinant BMPs and summarizes their use in preclinical trials.

摘要

生长因子的应用，如骨形态发生蛋白（BMPs），在骨科手术中显示出巨大的前景。具有骨诱导性的BMPs已成功用于脊柱融合和骨折愈合。本文描述了重组BMPs的研发和生产，并总结了它们在临床试验前的应用情况。