对局部粘度有响应的荧光传感器及其在脂质膜中液晶有序域成像的应用。
Fluorescent sensor responsive to local viscosity and its application to the imaging of liquid-ordered domain in lipid membranes.
作者信息
Yasuhara Kazuma, Sasaki Yoshihiro, Kikuchi Jun-ichi
机构信息
Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
出版信息
Colloids Surf B Biointerfaces. 2008 Nov 15;67(1):145-9. doi: 10.1016/j.colsurfb.2008.08.004. Epub 2008 Aug 15.
A novel fluorescent sensor responsive to local viscosity in the lipid bilayer membranes was designed and synthesized. The sensor changes its fluorescence intensity reflecting the local viscosity of its surrounding medium. The fluorescence measurement showed that the sensor is capable of discriminating between different phase states of lipid bilayer. In addition, the sensor visualized liquid-ordered microdomains on giant vesicles in terms of the microviscosity with a simple fluorescence technique.
设计并合成了一种对脂质双分子层膜局部粘度有响应的新型荧光传感器。该传感器会改变其荧光强度，以反映周围介质的局部粘度。荧光测量表明，该传感器能够区分脂质双分子层的不同相态。此外，该传感器通过一种简单的荧光技术，根据微粘度直观显示了巨型囊泡上的有序液体微区。
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