Gagneur A, Pinquier D, Aubert M, Soubeyrand B, Balu L, Brissaud O, Gras-Le-Guen C, Hau-Rainsard I, Mory O, Picherot G, De Pontual L, Stephan J-L, Reinert P
Réanimation pédiatrique et néonatalogie, département de pédiatrie, CHU de Brest, 2, avenue Foch, 29609 Brest, France.
Arch Pediatr. 2008 Oct;15(10):1525-30. doi: 10.1016/j.arcped.2008.07.011. Epub 2008 Sep 19.
Measles-vaccine coverage (MVC) increased significantly only beginning in 1983 based on the official recommendations. The majority of women born after 1983 should have vaccine-acquired rather than naturally derived immunity. Passively transferred measles antibodies (Mab) are expected to provide protection to offsprings during their 1st few months of life.
Compare neutralizing Mab titers according to age in women aged 12-40 years, i.e., born before and after 1983.
A multicenter seroepidemiological study was conducted in France in 2005-2006; 210 outpatient or hospitalized women were enrolled and classified into 4 age groups (12-18, 19-22, 23-30, and 31-40 years). Mab titers were assessed using a reference plaque reduction neutralization assay (protection threshold > 120 mIU/ml).
Ninety-four percent of subjects had a Mabs titer greater than 120 mIU/ml. Women born before 1983 had significantly higher geometric mean titers (GMTs) of Mabs than those born after 1983(1358 mIU/ml vs. 731 mIU/ml [p<0.001]). The comparison of the 4 cohorts showed a significant decrease (p<0.001) in GMTs of Mab in the female population with increasing age (670, 771, 1173, and 1821 mUI/ml, respectively, in the 12-18, 19-22, 23-30, and 31-40 years age groups). For the 1st time in France, we show in women of childbearing age that in 2005-2006 neutralizing Mab GMTs were far above protective threshold for all age groups. Women in younger age groups (with high MVC) have significantly lower Mab titers. A lower passive transfer of Mab to their offsprings could result in a shorter period of measles protection and question the measles vaccine 1st dose at 1 year.
根据官方建议，麻疹疫苗接种率（MVC）仅从1983年开始显著提高。1983年以后出生的大多数女性应具有疫苗获得性免疫而非自然获得性免疫。被动转移的麻疹抗体（Mab）有望在婴儿出生后的头几个月为其提供保护。
比较12至40岁女性（即1983年前后出生）的中和性Mab滴度。
2005 - 2006年在法国进行了一项多中心血清流行病学研究；招募了210名门诊或住院女性，并将其分为4个年龄组（12 - 18岁、19 - 22岁、23 - 30岁和31 - 40岁）。使用参考蚀斑减少中和试验评估Mab滴度（保护阈值>120 mIU/ml）。
94%的受试者Mab滴度大于120 mIU/ml。1983年以前出生的女性Mab的几何平均滴度（GMT）显著高于1983年以后出生的女性（1358 mIU/ml对731 mIU/ml [p<0.001]）。对4个队列的比较显示，随着年龄增长，女性群体中Mab的GMT显著下降（p<0.001）（12 - 18岁、19 - 22岁、23 - 30岁和31 - 40岁年龄组的GMT分别为670、771、1173和1821 mUI/ml）。在法国，我们首次在育龄女性中表明，在2005 - 2006年，所有年龄组的中和性Mab GMT都远高于保护阈值。较年轻年龄组（MVC高）的女性Mab滴度显著较低。Mab向其后代的被动转移较低可能导致麻疹保护期缩短，并对1岁时的第一剂麻疹疫苗提出质疑。
