Duester Gregg
Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA.
Cell. 2008 Sep 19;134(6):921-31. doi: 10.1016/j.cell.2008.09.002.
Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by providing an instructive signal for posterior neuroectoderm and foregut endoderm and a permissive signal for trunk mesoderm differentiation. At later stages, retinoic acid contributes to the development of the eye and other organs. Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells.
视黄酸是维生素A的衍生物，是脊椎动物器官形成过程中细胞间信号传导的重要组成部分。在早期发育过程中，视黄酸通过为后神经外胚层和前肠内胚层提供诱导信号以及为躯干中胚层分化提供允许信号来构建躯干。在后期阶段，视黄酸有助于眼睛和其他器官的发育。最近的研究表明，视黄酸可能主要以旁分泌方式起作用，并为控制多能细胞分化的细胞间信号网络提供了见解。
