高剂量皮质类固醇复发治疗的潜在副作用：急性泛发性脓疱性皮病（AGEP）。
Potential side effect of high-dose corticosteroid relapse treatment: acute generalized exanthematous pustulosis (AGEP).
作者信息
Ziemssen T, Bauer A, Bär M
机构信息
Department of Neurology, Multiple Sclerosis Center, University Clinic Carl Gustav Carus, University of Technology Dresden, Dresden, Germany.
出版信息
Mult Scler. 2009 Feb;15(2):275-7. doi: 10.1177/1352458508097218. Epub 2008 Sep 19.
INTRODUCTION
High-dose glucocorticosteroids (GC) are the treatment of choice for acute relapses in patients with multiple sclerosis as proven by several controlled clinical trials. The common adverse effects of GC are well known.
CASE PRESENTATION
In this study, we report on the exceptional case of a young female treated with intravenous high-dose prednisolone for optic neuritis who developed acute generalized exanthematous pustulosis (AGEP). AGEP is a rare cutaneous adverse reaction induced most frequently by antimicrobial or antihypertensive drugs and viral infections. It is characterized by a febrile erythematous and pustular rash and blood granulocytosis.
CONCLUSION
In our patient, switching to dexamethasone for the next relapse was tolerated well and is an option for treatment. AGEP is a rare adverse effect of corticosteroid treatment.
引言
多项对照临床试验已证实，大剂量糖皮质激素（GC）是治疗多发性硬化症患者急性复发的首选药物。GC的常见不良反应众所周知。
病例报告
在本研究中，我们报告了一例特殊病例，一名年轻女性因视神经炎接受静脉注射大剂量泼尼松龙治疗，随后发生了急性泛发性脓疱病（AGEP）。AGEP是一种罕见的皮肤不良反应，最常见的诱发因素是抗菌药物、抗高血压药物和病毒感染。其特征为发热性红斑和脓疱性皮疹以及血液粒细胞增多。
结论
在我们的患者中，下次复发时换用地塞米松耐受性良好，是一种治疗选择。AGEP是皮质类固醇治疗的罕见不良反应。
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