Cherif Y, Jallouli Moez, Mseddi M, Turki H, Bahloul Z
Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.
Department of Dermatology, Hedi Chaker University Hospital, Sfax, Tunisia.
Indian J Pharmacol. 2014 Mar-Apr;46(2):232-3. doi: 10.4103/0253-7613.129332.
Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction characterized by an acute episode of sterile pustules over erythematous-edematous skin. The main triggering drugs are antibiotics, mainly beta-lactam and macrolides. Non-steroid anti-inflammatory drugs may rarely be responsible. We describe a case of a woman with AGEP, who presented with generalized pustulosis lesions after the use of piroxicam for renal colic. The diagnosis was confirmed by the clinical and histological correlations and the dermatosis resolved after withdrawal of the drug.
急性泛发性脓疱病（AGEP）是一种严重的皮肤不良反应，其特征为在红斑水肿皮肤上急性发作无菌性脓疱。主要的诱发药物是抗生素，主要是β-内酰胺类和大环内酯类。非甾体抗炎药很少会引发该病。我们描述了一例AGEP女性患者，她在使用吡罗昔康治疗肾绞痛后出现了泛发性脓疱病皮损。通过临床和组织学相关性确诊，停药后皮肤病得到缓解。
