Duncan R, Peat G, Thomas E, Wood L, Hay E, Croft P
Arthritis Research Campaign National Primary Care Centre, Primary Care Sciences, Keele University, Keele, Staffordshire ST55BG, UK.
Rheumatology (Oxford). 2008 Nov;47(11):1704-7. doi: 10.1093/rheumatology/ken339. Epub 2008 Sep 19.
In radiographic OA (ROA) of the knee, how does radiographic severity and pattern of compartmental involvement influence symptoms?
Population-based study of 819 adults aged > or =50 yrs with knee pain. The severity of knee pain and function were measured using the Western Ontario and McMaster Universities scale. Three radiographic views of the knees were obtained.
Seven hundred and seventy-seven participants were eligible (mean age 65.5 yrs, 357 males). Higher ROA severity in each of the tibiofemoral (TF) and patellofemoral (PF) compartments was independently associated with higher mean pain scores (TF: F(2, 700) = 9.0, P < 0.0001, PF: F(2, 700) = 12.7, P < 0.0001). The same pattern was found for mean function scores (TF: F(2, 705) = 7.1, P = 0.001, PF: F(2, 705) = 15.9, P < 0.0001). If either the TF or PF compartment was affected by moderate/severe OA, the added presence of OA in the other compartment did not increase the mean pain or function scores.
It is the severity of radiographic disease within a compartment, rather than the distribution of radiographic disease between compartments that is associated with symptoms. ROA in the PF joint is associated with symptoms, emphasizing the importance of radiographic changes in his joint.
在膝关节的放射学骨关节炎（ROA）中，放射学严重程度和关节间受累模式如何影响症状？
对819名年龄≥50岁的膝关节疼痛成年人进行基于人群的研究。使用西安大略和麦克马斯特大学量表测量膝关节疼痛和功能的严重程度。获取膝关节的三张放射学影像。
777名参与者符合条件（平均年龄65.5岁，男性357名）。胫股（TF）和髌股（PF）关节间ROA严重程度越高，平均疼痛评分越高（TF：F(2, 700) = 9.0，P < 0.0001，PF：F(2, 700) = 12.7，P < 0.0001）。平均功能评分也呈现相同模式（TF：F(2, 705) = 7.1，P = 0.001，PF：F(2, 705) = 15.9，P < 0.0001）。如果TF或PF关节间受到中度/重度OA影响，另一关节间存在OA并不会增加平均疼痛或功能评分。
与症状相关的是关节间放射学疾病的严重程度，而非关节间放射学疾病的分布。PF关节的ROA与症状相关，强调了该关节放射学改变的重要性。
