Barr R D, Ouna N, Simpson J G, Bagshawe A F
Q J Med. 1976 Oct;45(180):647-59.
The mechanisms of blood coagulation and fibrinolysis have been evaluated in 28 black adult Africans with primary hepato-cellular carcinoma (HCC). A characteristic pattern of abnormalities has been defined. Dysfibrinogenaemia appears to be a useful biological marker for the disease. The reptilase test (RT) is a simple, reliable and sensitive means of detection of this metabolic abnormality. It is suggested that the RT should be used to screen populations at high risk of developing HCC, such as cirrhotics, in conjunction with alpha fetoprotein determinations, which, alone, are inadequate for the purpose. The haemostatic defect may have relevance to the pathogenesis of HCC, and further suggests a potentially useful, additional, therapeutic modality.
对28名患有原发性肝细胞癌（HCC）的成年非洲黑人进行了血液凝固和纤维蛋白溶解机制的评估。已确定了一种特征性的异常模式。异常纤维蛋白原血症似乎是该疾病的一种有用的生物学标志物。爬虫酶试验（RT）是检测这种代谢异常的一种简单、可靠且灵敏的方法。建议应将RT与甲胎蛋白测定结合起来，用于筛查罹患HCC风险较高的人群，如肝硬化患者，因为仅靠甲胎蛋白测定不足以达到此目的。止血缺陷可能与HCC的发病机制相关，并且进一步提示了一种潜在有用的附加治疗方式。
