Gardner Michael, Gardner David W, Sowers James R
Department of Medicine, University of Missouri, Columbia, MO 65212, USA.
Pediatr Endocrinol Rev. 2008 Aug;5 Suppl 4:964-8.
With recent increases in obesity among the pediatric age group, problems previously seen primarily in adults, such as type 2 diabetes and essential hypertension, are being more frequently diagnosed in young individuals. This has lead to interest in the development of the constellation of cardiovascular risk factors known as the cardiometabolic syndrome in the pediatric population. With these cardiovascular risk factors manifesting earlier, there is reason to be concerned that the earlier and longer exposure will result in earlier presentation of cardiovascular and microvascular events and lead to a devastating public health impact. In this review we examine the evidence for the increased prevalence of the cardiometabolic syndrome in the pediatric age group and the impact of childhood overweight on the prevalence of this syndrome in children as well as the impact on adult obesity and metabolic derangements.
随着近期儿科年龄组肥胖率的上升,以前主要在成年人中出现的问题,如2型糖尿病和原发性高血压,在年轻人中被诊断出的频率越来越高。这引发了人们对儿科人群中被称为心血管代谢综合征的一系列心血管危险因素发展情况的关注。由于这些心血管危险因素更早出现,有理由担心更早和更长时间的暴露会导致心血管和微血管事件更早发生,并对公共卫生造成毁灭性影响。在本综述中,我们研究了儿科年龄组中心血管代谢综合征患病率增加的证据,以及儿童超重对该综合征在儿童中的患病率的影响,以及对成人肥胖和代谢紊乱的影响。