Tomikawa S, Mezawa M, Yoshida Y, Saiga T, Shimizu Y
Eye Clinic, Hakujikai Memorial Hospital, Adachi-Ku, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Aug;97(8):967-74.
Lipoprotein (a) (Lp(a)) has been considered an independent risk factor for arteriosclerotic disease and its role in retinal vascular changes was studied in this report. The study was made on 160 patients of age 54 and above. They were divided into four groups depending upon their clinical background with or without the presence of diabetes mellitus (DM) and cerebral infarction (CI). The retinal vascular status of the patients was studied by ophthalmoscopic examination and the findings were graded according to Scheie's classification. We found that all the patients with retinal arterial hypertension and arteriosclerosis had a significant by high level of serum Lp (a). Similarly, serum Lp (a) level was higher in the patients with DM and CI than in the control subjects. These findings suggested that Lp (a) might influence the pathological changes of senile retinal arterioles. Moreover, we found a positive linear correlation between Lp (a) and plasminogen in patients with CI.
脂蛋白(a)（Lp(a)）被认为是动脉粥样硬化性疾病的独立危险因素，本报告研究了其在视网膜血管变化中的作用。该研究针对160名54岁及以上的患者进行。根据他们有无糖尿病（DM）和脑梗死（CI）的临床背景，将他们分为四组。通过检眼镜检查研究患者的视网膜血管状况，并根据谢伊分类法对检查结果进行分级。我们发现，所有患有视网膜动脉高血压和动脉硬化的患者血清Lp(a)水平均显著升高。同样，患有DM和CI的患者血清Lp(a)水平高于对照组。这些发现表明，Lp(a)可能影响老年视网膜小动脉的病理变化。此外，我们发现CI患者的Lp(a)与纤溶酶原之间存在正线性相关。
