Koizumi T, Zhu J
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
J Pharmacobiodyn. 1991 Mar;14(3):113-9. doi: 10.1248/bpb1978.14.113.
Response function, which correlates pharmacologic response intensity and the drug concentration, is defined assuming that the biophase (or the site of action) is consisted of the elements responsive to the drug, each of which is in a responding or non-responding state depending on the drug concentration in the biophase. The Hill equation, which has been widely used without a definite rationale, for correlation between pharmacologic response intensity and drug concentration is revealed as an approximate equation of the response function. Diuretic data obtained after administration of furosemide and reported previously are used for conformity assessment of the response function.
响应函数将药理反应强度与药物浓度关联起来，其定义基于这样的假设：生物相（或作用部位）由对药物有反应的元素组成，每个元素根据生物相中药物浓度处于反应或无反应状态。广泛使用但缺乏明确理论依据的用于关联药理反应强度和药物浓度的希尔方程，被证明是响应函数的近似方程。以前报道的给予呋塞米后获得的利尿数据用于响应函数的一致性评估。
