溶致液晶与角质层的结构脂质。

Lyotropic liquid crystals and the structural lipids of the stratum corneum.

作者信息

Kayali I, Suhery T, Friberg S E, Simion F A, Rhein L D

机构信息

Chemistry Department, Clarkson University, Potsdam, N.Y. 13699.

出版信息

J Pharm Sci. 1991 May;80(5):428-31. doi: 10.1002/jps.2600800506.

DOI:10.1002/jps.2600800506

PMID:1880720

Abstract

Lipids were extracted from human stratum corneum and the remaining corneocytes were reaggregated with different lyotropic liquid crystals. Water transport through the reaggregated stratum corneum was determined using a diffusion chamber according to Smith and Blank. The permeability constant for the reaggregated stratum corneum with natural lipids was 25-40% lower than that with the surfactant liquid crystals, but there was no significant difference between different liquid crystals.

摘要

从人角质层中提取脂质，剩余的角质形成细胞与不同的溶致液晶重新聚集。根据史密斯和布兰克的方法，使用扩散室测定通过重新聚集的角质层的水运输。含有天然脂质的重新聚集的角质层的渗透常数比含有表面活性剂液晶的角质层低25 - 40%，但不同液晶之间没有显著差异。