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[干细胞——克隆、可塑性、生物伦理]

[Stem cells--cloning, plasticity, bioethic].

作者信息

Pflegerl Pamina, Keller Thomas, Hantusch Brigitte, Hoffmann Thomas Sören, Kenner Lukas

机构信息

Klinisches Institut für Pathologie an der Medizinischen Universität in Wien, Osterreich.

出版信息

Wien Med Wochenschr. 2008;158(17-18):493-502. doi: 10.1007/s10354-008-0551-x.

Abstract

Stem cells with certain characteristics have become promising tools for molecular medicine. They have the potential to self-regenerate and to differentiate into specific tissues. Besides their great potential, embryonic stem cells (ESC) run the risk of enhanced tumorigenesis. The use of human embryonic stem cells (hESC) is ethically problematic because their isolation involves the destruction of human embryos. Recently developed methods generate are able to pluripotent stem cells from fibroblasts. Alternatives for ESC are adult stem cells (ASC) derived from bone marrow, cord blood, amniotic fluid and other tissues. The following article is on the basis of testimony of Lukas Kenner for the German Bundestag about the use of ESC for research, therapy and drug development. Ethical aspects are taken into consideration.

摘要

具有某些特性的干细胞已成为分子医学中很有前景的工具。它们具有自我更新以及分化为特定组织的潜力。除了巨大潜力外,胚胎干细胞(ESC)存在肿瘤发生增强的风险。人类胚胎干细胞(hESC)的使用存在伦理问题,因为其分离涉及人类胚胎的破坏。最近开发的方法能够从成纤维细胞生成多能干细胞。胚胎干细胞的替代物是源自骨髓、脐带血、羊水和其他组织的成体干细胞(ASC)。以下文章基于卢卡斯·肯纳为德国联邦议院提供的关于将胚胎干细胞用于研究、治疗和药物开发的证词。文中考虑了伦理方面的问题。

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