Denker Hans-Werner
Institut fuer Anatomie, Universitaetsklinikum, Universitaet Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany.
Reprod Biomed Online. 2009;19 Suppl 1:34-7. doi: 10.1016/s1472-6483(10)60062-4.
Recent developments in research on embryonic stem cells and induced pluripotent stem cells suggest that potentiality of cells should be a new focus in stem cell research ethics and policy. Successful reconstitution of viable embryos from induced pluripotent stem cells using tetraploid complementation has been reported and indicates a way for direct cloning of individuals from these cells. This together with recent observations on gastrulation and pattern formation processes in cultures of embryonic stem cells has considerable ethical relevance after the advent and worldwide spread of induced pluripotent stem cell technology. Available knowledge of the molecular basis of mammalian embryology now makes it possible to envisage ways to deal technically with the ethical dilemma of stem cell potentiality.
胚胎干细胞和诱导多能干细胞研究的最新进展表明，细胞的潜能应成为干细胞研究伦理与政策的新焦点。已有报道称利用四倍体互补技术从诱导多能干细胞成功重构出有活力的胚胎，这为从这些细胞直接克隆个体指明了一条道路。在诱导多能干细胞技术出现并在全球传播之后，这一成果连同近期关于胚胎干细胞培养中胚层形成和模式形成过程的观察结果，具有相当重要的伦理意义。目前关于哺乳动物胚胎学分子基础的已有知识，使人们能够设想出从技术上应对干细胞潜能伦理困境的方法。
