Devaki Pallaki Baby, Chandra Ranjit K, Geisser Peter
Department of Home Science, S.V. University, Tirupati, AP, India.
Arzneimittelforschung. 2008;58(8):389-97. doi: 10.1055/s-0031-1296526.
To assess the effects of supplementation with oral iron(III) hydroxide polymaltose complex on the iron status of adolescents with and without iron deficiency and anemia.
Adolescents of both sexes with varying iron status were allocated to four treatment groups by using inclusion criteria. Three of the four groups received iron(III) hydroxide polymaltose complex (IPC, Maltofer) containing 100 mg of iron 6 days a week for 8 months. The fourth group was given a placebo. Hematological parameters were assessed at the baseline and after 4 and 8 months of supplementation.
IPC supplementation resulted in a significant increase in iron parameters in all the three supplemented groups including correction of iron deficiency and anemia along with improvement in storage iron after 8 months. No side effects were noted in any of the supplemented subjects.
IPC supplementation improved the iron status of adolescents with and without iron deficiency and anemia. These data provide evidence that IPC is an easy-to-administer and well tolerated compound which can improve and normalize the iron status of iron deficient and anemic patients.
评估口服氢氧化铁聚麦芽糖复合物补充剂对有或无缺铁及贫血的青少年铁状态的影响。
根据纳入标准，将不同铁状态的青少年男女分配到四个治疗组。四个组中的三个组每周6天接受含100毫克铁的氢氧化铁聚麦芽糖复合物（IPC，麦芽糖铁），持续8个月。第四组给予安慰剂。在基线时以及补充剂服用4个月和8个月后评估血液学参数。
补充IPC导致所有三个补充组的铁参数显著增加，包括8个月后缺铁和贫血得到纠正以及储存铁改善。在任何补充剂服用者中均未观察到副作用。
补充IPC改善了有或无缺铁及贫血的青少年的铁状态。这些数据证明IPC是一种易于给药且耐受性良好的化合物，可改善缺铁和贫血患者的铁状态并使其正常化。
