Devaki Pallaki Baby, Chandra Ranjit K, Geisser Peter
Department of Home Science, Sri Venkateswara University, Tirupati, AP, India.
Arzneimittelforschung. 2009;59(6):303-10. doi: 10.1055/s-0031-1296401.
To assess the effects of iron supplementation on iron status, cognitive function, affective behavior and scholastic performance in adolescents with varying iron status.
Adolescents of both sexes with varying iron status were allocated to four treatment groups by using inclusion criteria. Three of the four groups (iron deficient anemic, iron deficient and control supplement) received iron(III) hydroxide polymaltose complex (IPC, Maltofer) containing 100 mg of elemental iron 6 days a week for 8 months, while the fourth group (control placebo) was given a placebo. Hematological parameters, cognitive function, affective behavior and scholastic performance were assessed at baseline, 4 months and 8 months of supplementation.
Cognitive and scholastic performance test scores for the three supplemented groups increased from baseline to 4 months and from 4 months to 8 months (with concomitant increases in hematological parameters), whereas no increase was observed in the placebo group. No increase was seen in affective behavior scores for any of the groups during or after supplementation.
IPC supplementation for eight months yielded significant improvements in cognitive function and scholastic performance in Indian adolescents with and without iron deficiency and anemia.
评估补充铁剂对不同铁状态青少年的铁状况、认知功能、情感行为和学业成绩的影响。
根据纳入标准，将不同铁状态的青少年男女分配到四个治疗组。四个组中的三个组（缺铁性贫血组、缺铁组和对照补充组）每周6天接受含100毫克元素铁的氢氧化铁聚麦芽糖复合物（IPC，麦芽糖铁），持续8个月，而第四组（对照安慰剂组）给予安慰剂。在补充的基线、4个月和8个月时评估血液学参数、认知功能、情感行为和学业成绩。
三个补充组的认知和学业成绩测试分数从基线到4个月以及从4个月到8个月均有所增加（同时血液学参数也增加），而安慰剂组未观察到增加。在补充期间或之后，任何组的情感行为分数均未增加。
对印度有或没有缺铁和贫血的青少年补充8个月的IPC可显著改善认知功能和学业成绩。
