Mathew M, Mathan M M, Mani K, George R, Jebakumar K, Dharamsi R, Kirubakaran C, Pereira S, Mathan V I
Wellcome Research Unit, Christian Medical College and Hospital, Vellore, India.
J Trop Med Hyg. 1991 Aug;94(4):253-60.
Bacterial, viral and parasitic enteric pathogens were detected in 692 of 916 children below 36 months of age with acute diarrhoea and in 289 of 587 matched controls. The rates of identification of only four groups of pathogens, rotavirus, Shigellae, Salmonella typhimurium and enterotoxigenic E. coli, were significantly higher in the patients. The prevalence of a variety of other enteric pathogens was similar in controls of patients. Shigellosis had a characteristic clinical profile but none of the other agents could be suspected on clinical grounds. The high prevalence of pathogens in controls suggested that the population may be partially protected against a variety of enteric pathogens and that final common pathways leading to diarrhoea may be activated by changes in the microbial ecology of the gut lumen.
在916名36个月以下患急性腹泻的儿童中，692名检测出细菌、病毒和寄生虫肠道病原体；在587名匹配的对照儿童中，289名检测出这些病原体。仅轮状病毒、志贺氏菌、鼠伤寒沙门氏菌和产肠毒素大肠杆菌这四类病原体在患者中的检出率显著更高。各种其他肠道病原体在患者和对照中的流行情况相似。志贺氏菌病有其特征性的临床症状，但其他病原体无法根据临床症状怀疑。对照中病原体的高流行率表明，该人群可能对多种肠道病原体有部分抵抗力，导致腹泻的最终共同途径可能因肠腔内微生物生态的变化而被激活。
