Sabry M
United States Naval Medical Research Unit No. 3 (NAMRU-3) Cairo, Egypt.
J Trop Med Hyg. 1991 Aug;94(4):283-90.
An index for experimental transmission of filariasis infection was first introduced by Kartman and subsequently modified by Wharton who defined it as 'the number of infective larvae per mosquito when the microfilaria count is 1.0 mm-3 of human blood'. Since mosquitoes may not imbibe the expected number of microfilariae from the donor's blood during feeding because of various interference phenomena and/or mechanisms, this paper presents the index mosquito meal (Index MM), based on the actual number of viable microfilariae that are observed in the mosquito gut immediately after feeding. The Index MM is defined as 'the number of infective larvae per mosquito when the microfilaria count is 1.0 mm-3 of mosquito blood meal'. The Index MM proved to be a more valid indicator of transmission potential than the Wharton Index when applied to the data of two controlled field studies where groups of laboratory-reared Culex pipiens molestus, the primary vector of filariasis in Egypt, were fed on volunteers having different microfilaraemic densities.
丝虫感染的实验传播指数最初由卡特曼提出，随后由沃顿进行了修改，他将其定义为“当人体血液中微丝蚴计数为每立方毫米1.0条时，每只蚊子体内感染性幼虫的数量”。由于蚊子在吸血过程中可能因各种干扰现象和/或机制而无法从供血者血液中摄取预期数量的微丝蚴，本文提出了基于喂食后立即在蚊子肠道中观察到的活微丝蚴实际数量的指数蚊餐（Index MM）。Index MM被定义为“当蚊子血餐中微丝蚴计数为每立方毫米1.0条时，每只蚊子体内感染性幼虫的数量”。当将Index MM应用于两项对照现场研究的数据时，事实证明它是比沃顿指数更有效的传播潜力指标，在这两项研究中，将实验室饲养的埃及丝虫主要传播媒介骚扰库蚊成群喂食给具有不同微丝蚴血症密度的志愿者。
