Wang P, Ren Z, Zhang Y
Shandong Institute of Parasitic Diseases, Jining.
Zhonghua Yu Fang Yi Xue Za Zhi. 1996 May;30(3):136-8.
A longitudinal study was conducted to explore transmission dynamics and epidemic trend of bancroftian filariasis in Huayuan Village, Shengli Township, Tancheng County, Shandong Province, a previous highly endemic area of it, from 1984, the fifth year after its preliminary eradication, to 1993, without any control measures being taken. Results showed proportions of residents with microfilaremia decreased to 0.12% in 1993 from 0.56% before the study. Eight of the nine microfilaria carriers before the study became negative spontaneously. Six new microfilaria carriers were detected during the study period, but five of them converted negative in three or four years. Negative conversion rate of blood IgG4 in microfilaremia cases was 88.89% by the end of the study. Natural infection rate in mosquitoes dropped year by year, with 0.21%, 0.19% and 0.06% for 1984, 1985 and 1986, respectively, and no filarial larvae was found in them in 1993 and natural transmission potential dropped from 3.47 to zero. It suggested the threshold for transmission of filariasis was not reached and the transmission was close to the end, with the rates of mosquito biting of 24.1-52.5 and 13.5-21.0 times per person, per night, for those using or non-using mosquito net, respectively.
在山东省郯城县胜利乡花园村开展了一项纵向研究，以探索班氏丝虫病的传播动态和流行趋势。花园村曾是该病的高流行区，自1984年（初步根除后的第5年）至1993年，期间未采取任何控制措施。结果显示，居民微丝蚴血症比例从研究前的0.56%降至1993年的0.12%。研究前9名微丝蚴携带者中有8人自然转阴。研究期间检测到6名新的微丝蚴携带者，但其中5人在3至4年内转阴。研究结束时，微丝蚴血症病例的血液IgG4阴转率为88.89%。蚊虫自然感染率逐年下降，1984年、1985年和1986年分别为0.21%、0.19%和0.06%，1993年未发现丝虫幼虫，自然传播潜能从3.47降至零。这表明未达到丝虫病传播阈值，传播已接近尾声，使用蚊帐者和未使用蚊帐者每人每晚的蚊虫叮咬次数分别为24.1 - 52.5次和13.5 - 21.0次。
