Henquet C, Rosa A, Delespaul P, Papiol S, Fananás L, van Os J, Myin-Germeys I
Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands.
Acta Psychiatr Scand. 2009 Feb;119(2):156-60. doi: 10.1111/j.1600-0447.2008.01265.x. Epub 2008 Sep 18.
A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted.
The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (n = 31) and healthy controls (n = 25).
Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability.
The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life.
儿茶酚-O-甲基转移酶基因（COMT Val(158)Met）中的功能多态性可能会调节大麻诱发精神病的作用。为了将这一发现扩展到日常生活动态影响方面，开展了一项关于使用大麻后精神病症状的瞬时评估研究。
采用经验抽样技术收集精神病性障碍患者（n = 31）和健康对照者（n = 25）在日常生活中使用大麻及症状出现情况的数据。
基于心理测量学上的精神病易感性先前证据，携带COMT Val(158)Met Val等位基因的个体（而非Met/Met基因型个体）在接触大麻后幻觉增加。
研究结果证实，在有心理测量学证据表明存在精神病易感性的人群中，COMT Val(158)Met基因型可调节日常生活中大麻与精神病现象之间的关联。
