儿茶酚-O-甲基转移酶（COMT）缬氨酸158位甲硫氨酸多态性对应激性精神病的调节作用
COMT Val158Met moderation of stress-induced psychosis.
作者信息
Stefanis Nicholas C, Henquet Cécile, Avramopoulos Dimitrios, Smyrnis Nikolaos, Evdokimidis Ioannis, Myin-Germeys Inez, Stefanis Costas N, Van Os Jim
机构信息
Division of Psychological Medicine, Institute of Psychiatry, London, UK.
出版信息
Psychol Med. 2007 Nov;37(11):1651-6. doi: 10.1017/S0033291707001080. Epub 2007 Jul 20.
BACKGROUND
Exposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderates the psychosis-inducing effects of stress.
METHOD
A semi-experimental stress exposure paradigm was used in a sample of 306 genotyped young men (aged 19-24 years), in whom measures of psychotic symptoms were obtained at recruitment in the Greek army (exposed condition) and again after 18 months of military training (unexposed condition).
RESULTS
Stress exposure at army induction was associated with an increased level of psychotic symptoms. In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025).
CONCLUSION
The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms.
背景
经历应激性生活事件会增加患精神障碍的风险。此外，对应激的反应性增加似乎是精神病易感性的一部分。本研究旨在调查儿茶酚-O-甲基转移酶（COMT Val(158)Met）基因的功能多态性是否会调节应激诱导精神病的作用。
方法
对306名进行了基因分型的年轻男性（年龄19 - 24岁）样本采用半实验性应激暴露范式，在希腊军队招募时（暴露条件）以及军事训练18个月后（未暴露条件）获取他们的精神病症状测量数据。
结果
入伍时的应激暴露与精神病症状水平升高有关。此外，与Met/Met基因型个体相比，COMT Val(158)Met Val等位基因携带者对应激对精神病结局的影响更敏感（交互作用检验：χ2 = 5.02，自由度 = 1，p = 0.025）。
结论
COMT Val(158)Met基因型可能会调节应激对精神病症状的影响。
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