Christensen Karina, Schrøder Henrik Daa, Kristensen Bjarne Winther
Odense Universitetshospital, Afdeling for Klinisk Patologi, Odense C.
Ugeskr Laeger. 2008 Sep 15;170(38):2968-70.
Despite intensive research, gliomas still lead to death in most cases. The isolation of brain tumour stem cells from gliomas has paved the way for a growing body of evidence suggesting that these cells are responsible for the resistance of gliomas towards conventional therapy. Recent results suggest that the growth of brain tumours can be inhibited by treatment strategies targeting the brain tumour stem cells. Here, the brain tumour stem cell paradigm is described with a focus on tumour stem cell characteristics and the role of this subpopulation of tumour cells in the resistance towards radiation and chemotherapy.
尽管进行了深入研究，但在大多数情况下，胶质瘤仍会导致死亡。从胶质瘤中分离出脑肿瘤干细胞，为越来越多的证据铺平了道路，这些证据表明这些细胞是胶质瘤对传统疗法产生抗性的原因。最近的结果表明，针对脑肿瘤干细胞的治疗策略可以抑制脑肿瘤的生长。在此，将描述脑肿瘤干细胞范式，重点关注肿瘤干细胞特征以及该肿瘤细胞亚群在抗辐射和化疗中的作用。
