Gabelle A, Roche S, Lehmann S
CNRS UPR 1142 Stem cells and neurodegenerative diseases, institut de génétique humaine, Montpellier, France.
Rev Neurol (Paris). 2009 Mar;165(3):213-22. doi: 10.1016/j.neurol.2008.05.004. Epub 2008 Jul 7.
Given the current developments of therapeutic strategies in the field of neurodegenerative disorders, exact diagnosis, especially at an early stage, is becoming increasingly crucial for optimal patient care. Importantly, the new diagnosis criteria of dementia include functional imagery as well as CSF biomarkers. Proteomics investigations of these CSF biomarkers have produced quite promising results. The interest of CSF analysis resides in the anatomical and pathophysiological characteristics of this fluid. In this article, we will review current proteomics investigations of CSF which have led to the discovery and validation of biomarkers, mainly in the field of neurodegenerative disorders in Alzheimer's disease.
鉴于神经退行性疾病领域治疗策略的当前发展，准确诊断，尤其是在早期阶段，对于为患者提供最佳护理变得越来越关键。重要的是，痴呆症的新诊断标准包括功能成像以及脑脊液生物标志物。对这些脑脊液生物标志物的蛋白质组学研究已经产生了相当有前景的结果。脑脊液分析的意义在于这种液体的解剖学和病理生理学特征。在本文中，我们将回顾目前对脑脊液的蛋白质组学研究，这些研究已促成生物标志物的发现和验证，主要是在阿尔茨海默病等神经退行性疾病领域。
