老年人不明原因贫血
Unexplained anemia in the elderly.
作者信息
Makipour Sasan, Kanapuru Bindu, Ershler William B
机构信息
Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
出版信息
Semin Hematol. 2008 Oct;45(4):250-4. doi: 10.1053/j.seminhematol.2008.06.003.
Abstract
Among the elderly, anemia occurs with increasing frequency with each advancing decade. Unlike when anemia occurs in younger adults, the cause of anemia in the elderly is oftentimes not readily apparent or attributable to a single cause. However, this commonly observed form of anemia in the elderly (termed unexplained anemia [UA]) can generally be dissected to its root causes, which include renal insufficiency, inflammation, testosterone deficiency, and stem cell proliferative decline. Myelodysplasia (MDS) occurs commonly in this age group but can and should, for both diagnostic and therapeutic considerations, be distinguished from UA.
摘要
在老年人中，贫血的发生率随着年龄每增长十岁而增加。与年轻人患贫血不同，老年人贫血的原因通常并不明显，也不能归因于单一原因。然而，老年人中这种常见的贫血形式（称为不明原因贫血[UA]）通常可以剖析出其根本原因，包括肾功能不全、炎症、睾酮缺乏和干细胞增殖能力下降。骨髓增生异常综合征（MDS）在这个年龄组中很常见，但出于诊断和治疗的考虑，它可以且应该与不明原因贫血区分开来。
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