Ghosh Nilanjan, Matsui William
Division of Hematologic Malignancies, Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA.
Cancer Lett. 2009 May 8;277(1):1-7. doi: 10.1016/j.canlet.2008.08.005. Epub 2008 Sep 21.
Several key observations providing evidence for the cancer stem cell hypothesis and insights into the unique biology of these cells have come from the study of multiple myeloma. These include evidence that cancer cells may be functionally heterogeneous in spite of their genetic homogeneity and that malignant progenitors share many biological features with normal adult stem cells including drug resistance and regulatory processes governing self-renewal. We review studies that have examined clonogenic cells in multiple myeloma, highlight controversies regarding the cell of origin in multiple myeloma, and discuss potential targeting strategies.
多项关键观察结果为癌症干细胞假说提供了证据，并深入揭示了这些细胞独特的生物学特性，这些观察结果来自于对多发性骨髓瘤的研究。这些证据包括：尽管癌细胞在基因上具有同质性，但其在功能上可能存在异质性；恶性祖细胞与正常成体干细胞具有许多共同的生物学特性，包括耐药性和控制自我更新的调节过程。我们回顾了研究多发性骨髓瘤中克隆形成细胞的研究，强调了关于多发性骨髓瘤起源细胞的争议，并讨论了潜在的靶向策略。
