Okamoto S, Takahashi H, Minoura K, Fujita N, Yoshimura M
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine.
Rinsho Byori. 1991 Jun;39(6):651-5.
Since the level of fibrinogen degradation products (FDP) are elevated with severity of inflammation, we assumed that FDP in the cerebrospinal fluid (CSF) could be a marker of meningitis. We, therefore, measured FDP in the CSF of 6 patients with bacterial meningitis and 6 aseptic meningitis. The range of FDP levels in the CSF in patients without meningitis was 0.21 +/- 0.01 microgram/ml. While, the level of FDP in patients with aseptic meningitis (0.43 +/- 0.10 microgram/ml) and in bacterial meningitis (1.78 +/- 0.42 micrograms/ml) was significantly elevated (p less than 0.05). The value was significantly (p less than 0.01) higher in the group of septic meningitis than in aseptic meningitis. In one patient with septic meningitis, we could measure FDP in the CSF several times during the course of the disease, in which the level of FDP got into the high range earlier than the changes in levels of protein, glucose and cell counts in the CSF. FDP in the CSF well correlated to the clinical course of the meningitis. Eventually, we found that FDP in the CSF was definitely elevated in patients with bacterial meningitis, whereas it was slightly elevated in patients with aseptic meningitis. The measurement of FDP in the CSF, therefore, is concluded to be useful for the differential diagnosis of meningitis, and to assess the clinical course of meningitis.
由于纤维蛋白原降解产物（FDP）水平会随着炎症严重程度升高，我们推测脑脊液（CSF）中的FDP可能是脑膜炎的一个标志物。因此，我们检测了6例细菌性脑膜炎患者和6例无菌性脑膜炎患者脑脊液中的FDP。无脑膜炎患者脑脊液中FDP水平范围为0.21±0.01微克/毫升。而无菌性脑膜炎患者（0.43±0.10微克/毫升）和细菌性脑膜炎患者（1.78±0.42微克/毫升）脑脊液中的FDP水平显著升高（p<0.05）。化脓性脑膜炎组的值显著高于无菌性脑膜炎组（p<0.01）。在1例化脓性脑膜炎患者中，我们在病程中多次检测其脑脊液中的FDP，其中FDP水平比脑脊液中蛋白质、葡萄糖和细胞计数水平的变化更早进入高值范围。脑脊液中的FDP与脑膜炎的临床病程密切相关。最终，我们发现细菌性脑膜炎患者脑脊液中的FDP确实升高，而无菌性脑膜炎患者脑脊液中的FDP略有升高。因此，脑脊液中FDP的检测对脑膜炎的鉴别诊断及评估脑膜炎的临床病程具有重要意义。
