Yousef Mokhtar I, El-Demerdash Fatma M, Radwan Fatma M E
Department of Home Economic, Faculty of Specific Education, Alexandria University, 14 Mohamed Amin Shohaib Street, Moustafa Kamel, P.O. Box Roushdi, Alexandria 21529, Egypt.
Food Chem Toxicol. 2008 Nov;46(11):3506-11. doi: 10.1016/j.fct.2008.08.031. Epub 2008 Sep 2.
The present study was undertaken to evaluate the therapeutic efficacy of curcumin in terms of normalization of altered biochemical parameters following sodium arsenite treatment in rats. Animals were divided into four groups. The first group was used as control. While, groups 2, 3 and 4 were orally treated with curcumin (Cur, 15 mg/kg BW), sodium arsenite (Sa, 5 mg/kg BW) and sodium arsenite plus curcumin, respectively. Results showed that the activities of transaminases and phosphatases were significantly decreased in liver due to Sa administration, whereas increased in plasma. The activity of brain and plasma acetylcholinesterase (AChE) was decreased in rats treated with Sa. Also, Sa significantly decreased plasma total protein (TP), albumin (Alb) and high density lipoprotein-cholesterol (HDL-c), while increased glucose, urea, creatinine, bilirubin, total lipid (TL), cholesterol, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c). Curcumin alone decreased the levels of glucose, urea, creatinine, TL, cholesterol, TG and LDL-c. Curcumin reduced Sa-induced transaminases, phosphatases, glucose, urea, creatinine, bilirubin, TL, cholesterol and TG. Moreover, curcumin induced Sa-reduced liver transaminases and phosphatases, plasma and brain AChE, and the levels of TP and Alb. Experimental results, therefore suggested that curcumin protects arsenic induced biochemical alterations in rats.
本研究旨在评估姜黄素对亚砷酸钠处理的大鼠生化参数改变正常化的治疗效果。将动物分为四组。第一组用作对照。而第2、3和4组分别口服姜黄素（Cur，15毫克/千克体重）、亚砷酸钠（Sa，5毫克/千克体重）和亚砷酸钠加姜黄素。结果表明，由于给予亚砷酸钠，肝脏中转氨酶和磷酸酶的活性显著降低，而血浆中则升高。用亚砷酸钠处理的大鼠脑和血浆乙酰胆碱酯酶（AChE）的活性降低。此外，亚砷酸钠显著降低血浆总蛋白（TP）、白蛋白（Alb）和高密度脂蛋白胆固醇（HDL-c），同时升高葡萄糖、尿素、肌酐、胆红素、总脂质（TL）、胆固醇、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-c）。单独使用姜黄素可降低葡萄糖、尿素、肌酐、TL、胆固醇、TG和LDL-c的水平。姜黄素降低了亚砷酸钠诱导的转氨酶、磷酸酶、葡萄糖、尿素、肌酐、胆红素、TL、胆固醇和TG。此外，姜黄素诱导亚砷酸钠降低的肝脏转氨酶和磷酸酶、血浆和脑AChE以及TP和Alb的水平。因此，实验结果表明姜黄素可保护大鼠免受砷诱导的生化改变。
