Tet 42，一种从深层陆地地下细菌中分离出的新型四环素抗性决定因子。
Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria.
作者信息
Brown Mindy G, Mitchell Elizabeth H, Balkwill David L
机构信息
Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.
出版信息
Antimicrob Agents Chemother. 2008 Dec;52(12):4518-21. doi: 10.1128/AAC.00640-08. Epub 2008 Sep 22.
Abstract
Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains.
摘要
Tet 42是一种来自深层地下细菌的新型四环素抗性决定因子，经鉴定发现它与TetA(Z)有30%的序列相似性。该蛋白是一种假定的外排泵，与先前鉴定的泵具有共同特征，包括一个反向转录的TetR阻遏物、一个保守的GxxSDRxGRR基序和跨膜结构域。
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