Roche Pierre-Hugues, Pellet William, Moriyama Takuzo, Thomassin Jean-Marc
Service de Neurochirurgie, Hôpital Sainte-Marguerite, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
Prog Neurol Surg. 2008;21:73-78. doi: 10.1159/000156708.
For large vestibular schwannomas (VSs) for which removal is the primary therapy, the goals are complete tumor resection and maintenance of normal neurological function. The authors analyzed their results about facial nerve preservation, extent of resection and complications following resection of large VSs via a widened translabyrinthine approach. Between 1991 and 2001, 110 patients with a unilateral large VS (Koos stage IV) were operated on using the same technique in the same institution. The main steps of the operative technique were detailed and the clinical outcomes analyzed and compared with the results that were extracted from matched series in the literature. The main postoperative complications were cerebrospinal fluid leakage through the scalp wound in 4%, cerebrospinal fluid rhinorrhea in 4% requiring surgical revision in 3%. One percent of meningitis, 1% of posterior fossa hematoma and 4% of transient lower cranial nerve palsies were observed. There was no death related to the surgery. Total tumor removal was achieved in 85% of cases, near-total in 11% and subtotal in 4% of cases. Sixty-two percent of patients obtained normal to near-normal facial function (House-Brackmann grades 1 and 2). The authors suggest that the translabyrinthine approach is a suitable route for the safe removal of large VSs.
对于以切除为主要治疗手段的大型前庭神经鞘瘤(VSs),目标是实现肿瘤全切并维持正常神经功能。作者分析了通过扩大经迷路入路切除大型VSs后面神经保留、切除范围及并发症的结果。1991年至2001年期间,110例单侧大型VS(库斯IV期)患者在同一机构采用相同技术进行手术。详细介绍了手术技术的主要步骤,并分析了临床结果,与从文献中匹配系列提取的结果进行比较。主要术后并发症包括4%的头皮伤口脑脊液漏、4%的脑脊液鼻漏(其中3%需要手术修复)。观察到1%的脑膜炎、1%的后颅窝血肿和4%的短暂性下颅神经麻痹。无手术相关死亡。85%的病例实现了肿瘤全切,11%为近全切,4%为次全切。62%的患者获得了正常至接近正常的面部功能(House-Brackmann分级1级和2级)。作者认为经迷路入路是安全切除大型VSs的合适途径。